Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Research Articles, Development/Plasticity/Repair

Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length

Matthew Swire, Peggy Assinck, Peter A. McNaughton, David A. Lyons, Charles ffrench-Constant and Matthew R. Livesey
Journal of Neuroscience 22 September 2021, 41 (38) 7954-7964; https://doi.org/10.1523/JNEUROSCI.2463-20.2021
Matthew Swire
1Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom
2Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
3Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peggy Assinck
1Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter A. McNaughton
4Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Lyons
2Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles ffrench-Constant
1Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew R. Livesey
2Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
5Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2463-20.2021
PubMed 
34341156
Published By 
Society for Neuroscience
History 
  • Received September 21, 2020
  • Revision received June 16, 2021
  • Accepted July 6, 2021
  • First published August 2, 2021.
  • Version of record published September 22, 2021.
Copyright & Usage 
Copyright © 2021 Swire et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Matthew Swire1,2,3,
  2. Peggy Assinck1,
  3. Peter A. McNaughton4,
  4. David A. Lyons2,
  5. Charles ffrench-Constant1, and
  6. Matthew R. Livesey2,5
  1. 1Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom
  2. 2Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
  3. 3Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
  4. 4Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, United Kingdom
  5. 5Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, United Kingdom
View Full Text

Author contributions

  1. Author contributions: M.S., D.A.L., C.f.-C., and M.L. designed research; M.S., P.A., and M.L. performed research; M.S., P.M., C.f.-C., and M.L. contributed unpublished reagents/analytic tools; M.S. and M.L. analyzed data; M.S., D.A.L., C.f.-C., and M.L. wrote the paper.

Disclosures

    • Received September 21, 2020.
    • Revision received June 16, 2021.
    • Accepted July 6, 2021.
  • This work was supported by a Wellcome Trust Senior Investigator Award to C.f-C., a Wellcome Trust Senior Research Fellowship award (214244/Z/18/Z) to D.A.L. and a Royal Society of P.A. holds a Marie Curie Individual Fellowship. We thank past and present members of the ffrench-Constant and Lyons laboratories for assistance and discussions. We also thank Dr. Sam Booker for helpful discussions on electrophysiological recordings. In addition, we thank Professor William Richardson for the use of reagents and facilities. Finally, we thank the University of Edinburgh for animal husbandry and support facilities.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Matthew R. Livesey at M.R.Livesey{at}Sheffield.ac.uk or Matthew Swire at m.swire{at}ucl.ac.uk

Funding

  • Wellcome Trust (Wellcome)

  • Royal Society of Edinburgh (RSE)

  • Marie Curie Individual Fellowship

Other Version

  • previous version (August 02, 2021).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-06-20
to
E.g., 2025-06-20

Article usage: August 2021 to May 2025

AbstractFullPdf
Aug 202110840337
Sep 2021682695259
Oct 2021187383105
Nov 20219816366
Dec 20214244738
Total 202120931688805
Jan 20227999151
Feb 20223217658
Mar 2022369178
Apr 2022287947
May 2022317248
Jun 2022246645
Jul 2022157131
Aug 2022167233
Sep 2022157033
Oct 20222310943
Nov 202252618
Dec 20225248
Total 20223091847493
Jan 2023247444
Feb 2023145036
Mar 2023227640
Apr 2023157837
May 2023205627
Jun 2023154027
Jul 2023204335
Aug 2023233826
Sep 2023253628
Oct 2023267049
Nov 2023245239
Dec 2023156437
Total 2023243677425
Jan 2024268743
Feb 2024125737
Mar 2024226046
Apr 2024108930
May 2024306133
Jun 2024136537
Jul 2024275343
Aug 2024135145
Sep 2024215250
Oct 2024235637
Nov 2024197958
Dec 2024225540
Total 2024238765499
Jan 2025156049
Feb 2025198642
Mar 2025166230
Apr 2025185632
May 202582021
Total 202576284174
Total295952612396
Back to top

In this issue

The Journal of Neuroscience: 41 (38)
Journal of Neuroscience
Vol. 41, Issue 38
22 Sep 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length
Matthew Swire, Peggy Assinck, Peter A. McNaughton, David A. Lyons, Charles ffrench-Constant, Matthew R. Livesey
Journal of Neuroscience 22 September 2021, 41 (38) 7954-7964; DOI: 10.1523/JNEUROSCI.2463-20.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length
Matthew Swire, Peggy Assinck, Peter A. McNaughton, David A. Lyons, Charles ffrench-Constant, Matthew R. Livesey
Journal of Neuroscience 22 September 2021, 41 (38) 7954-7964; DOI: 10.1523/JNEUROSCI.2463-20.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • HCN
  • myelin
  • myelination
  • oligodendrocyte
  • physiology
  • sheath

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Chemogenetic disruption of monkey perirhinal neurons projecting to rostromedial caudate impairs associative learning
  • Specializations in amygdalar and hippocampal innervation of the primate nucleus accumbens shell
  • “What” and “When” Predictions Jointly Modulate Speech Processing
Show more Research Articles

Development/Plasticity/Repair

  • LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice
  • Acoustic Enrichment Prevents Early Life Stress-Induced Disruptions in Sound Azimuth Processing
  • Concentration-Dependent Bidirectional Modification of Evoked Synaptic Transmission by Gadolinium and Adverse Effects of Gadolinium-Based Contrast Agent
Show more Development/Plasticity/Repair
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.