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Research Articles, Behavioral/Cognitive

l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry

Marta De Felice, Justine Renard, Roger Hudson, Hanna J. Szkudlarek, Brian J. Pereira, Susanne Schmid, Walter J. Rushlow and Steven R. Laviolette
Journal of Neuroscience 27 January 2021, 41 (4) 739-750; https://doi.org/10.1523/JNEUROSCI.1050-20.2020
Marta De Felice
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Justine Renard
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Roger Hudson
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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  • ORCID record for Roger Hudson
Hanna J. Szkudlarek
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Brian J. Pereira
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Susanne Schmid
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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  • ORCID record for Susanne Schmid
Walter J. Rushlow
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
3Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Steven R. Laviolette
1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
3Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1050-20.2020
PubMed 
33268546
Published By 
Society for Neuroscience
History 
  • Received May 2, 2020
  • Revision received September 15, 2020
  • Accepted September 22, 2020
  • First published December 2, 2020.
  • Version of record published January 27, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Marta De Felice1,2,
  2. Justine Renard1,2,
  3. Roger Hudson1,2,
  4. Hanna J. Szkudlarek1,2,
  5. Brian J. Pereira1,2,
  6. Susanne Schmid2,
  7. Walter J. Rushlow1,2,3, and
  8. Steven R. Laviolette1,2,3
  1. 1Addiction Research Group, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
  2. 2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
  3. 3Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
View Full Text

Author contributions

  1. Author contributions: M.D.F. and S.R.L. designed research; M.D.F., J.R., R.H., H.J.S., B.J.P., and W.J.R. performed research; M.D.F., R.H., H.J.S., S.S., and W.J.R. analyzed data; M.D.F. and S.R.L. wrote the paper.

Disclosures

    • Received May 2, 2020.
    • Revision received September 15, 2020.
    • Accepted September 22, 2020.
  • This work was supported by CanaQuest Medical Corp and MITACS Canada.

  • M.D.F. and S.R.L. declare that the results of this study have been included in intellectual property: U.S. Patent 62/730,253, “L-theanine and tetrahydrocannabinol formulation” (Provisional filled September 12, 2018). The authors declare no other competing financial interests.

  • Correspondence should be addressed to Steven R. Laviolette at steven.laviolette{at}schulich.uwo.ca

Funding

  • Mitacs

  • CanaQuest Medical Corp

Other Version

  • previous version (December 02, 2020).
  • You are viewing the most recent version of this article.

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Total 202541324981805
Total13605140136303
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The Journal of Neuroscience: 41 (4)
Journal of Neuroscience
Vol. 41, Issue 4
27 Jan 2021
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l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry
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l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry
Marta De Felice, Justine Renard, Roger Hudson, Hanna J. Szkudlarek, Brian J. Pereira, Susanne Schmid, Walter J. Rushlow, Steven R. Laviolette
Journal of Neuroscience 27 January 2021, 41 (4) 739-750; DOI: 10.1523/JNEUROSCI.1050-20.2020

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l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry
Marta De Felice, Justine Renard, Roger Hudson, Hanna J. Szkudlarek, Brian J. Pereira, Susanne Schmid, Walter J. Rushlow, Steven R. Laviolette
Journal of Neuroscience 27 January 2021, 41 (4) 739-750; DOI: 10.1523/JNEUROSCI.1050-20.2020
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Keywords

  • adolescence
  • cognition
  • dopamine
  • l-theanine
  • mesocorticolimbic
  • THC

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