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Research Articles, Behavioral/Cognitive

Causal Evidence for a Double Dissociation between Object- and Scene-Selective Regions of Visual Cortex: A Preregistered TMS Replication Study

Miles Wischnewski and Marius V. Peelen
Journal of Neuroscience 27 January 2021, 41 (4) 751-756; https://doi.org/10.1523/JNEUROSCI.2162-20.2020
Miles Wischnewski
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 HR, Nijmegen, The Netherlands
2Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455
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Marius V. Peelen
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 HR, Nijmegen, The Netherlands
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    Figure 1.

    A, Examples of stimuli for each category. B, TMS sites used in the present study. OPA and LOC were based on fMRI coordinates from previous studies [i.e., for the LOC Talairach coordinates: 45, −74, 0 (Pitcher et al., 2009); and for the OPA Talairach coordinates: 34, −77, 21 (Julian et al., 2016)]. C, Example trial of the 4AFC object/scene recognition task. Five TMS pulses at a rate of 10 Hz were delivered at the onset of the stimulus.

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    Figure 2.

    A, Results of the present study (N = 72). The findings are similar to those of Dilks et al. (2013) showing decreased performance for scene recognition during TMS over OPA (compared with vertex) and decreased performance for object recognition during TMS over LOC (compared with vertex). B, Average and individual data of the LOC effect (percentage performance difference vertex – LOC during object recognition) and OPA effect (percentage performance difference vertex – OPA during scene recognition) for both the present study and Dilks et al. (2013). C, Percentages of participants susceptible to TMS over OPA, LOC, both, or neither. D, LOC (red) and OPA (blue) effect for the first half and second half of the experiment. E, LOC (red) and OPA (blue) effect per category. In all graphs: *p < 0.05, **p < 0.01, ***p < 0.001, with error bars reflecting the SEM.

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The Journal of Neuroscience: 41 (4)
Journal of Neuroscience
Vol. 41, Issue 4
27 Jan 2021
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Causal Evidence for a Double Dissociation between Object- and Scene-Selective Regions of Visual Cortex: A Preregistered TMS Replication Study
Miles Wischnewski, Marius V. Peelen
Journal of Neuroscience 27 January 2021, 41 (4) 751-756; DOI: 10.1523/JNEUROSCI.2162-20.2020

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Causal Evidence for a Double Dissociation between Object- and Scene-Selective Regions of Visual Cortex: A Preregistered TMS Replication Study
Miles Wischnewski, Marius V. Peelen
Journal of Neuroscience 27 January 2021, 41 (4) 751-756; DOI: 10.1523/JNEUROSCI.2162-20.2020
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Keywords

  • lateral occipital cortex
  • object recognition
  • occipital place area
  • scene recognition
  • transcranial magnetic stimulation

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