Article Information
- Received March 8, 2021
- Revision received August 17, 2021
- Accepted August 19, 2021
- First published August 26, 2021.
- Version of record published October 13, 2021.
Author Information
- 1Department of Pharmacology, University of California San Diego, La Jolla, California 92093
- 2Department of Neurosciences, University of California San Diego, La Jolla, California 92093
- 3Alzheimer's Disease Research Center, University of California San Diego, La Jolla, California 92093
- 4Center for Circadian Biology, University of California San Diego, La Jolla, California 92093
Author contributions
Author contributions: M.W. and W.J.J. designed research; M.W., C.Z.L., and E.A.B. performed research; M.W. and R.A.R. contributed unpublished reagents/analytic tools; M.W., C.Z.L., and E.A.B. analyzed data; M.W. wrote the first draft of the paper; M.W., C.Z.L., R.A.R., and W.J.J. edited the paper; M.W. and W.J.J. wrote the paper.
Disclosures
- Received March 8, 2021.
- Revision received August 17, 2021.
- Accepted August 19, 2021.
Acknowledgements: We thank Jeffrey Metcalf and Sara Shuldberg from the Rissman lab and Shiley-Marcos Alzheimer's Disease Research Center for providing human brain tissue and CSF; Nicole Purcell and Joan Brown for providing rat tissue for primary neuronal cultures; Eric Griffis and Daphne Bindels from the Nikon Imaging Center at University of California San Diego for advice with microscopy; and the late Dr. Peter Davies for donating antibody PHF-1. This work was supported by National Institutes of Health Grants R01 GM125080 to WJJ and P30 AG062429 to RAR.
The authors declare no competing financial interests.
- Correspondence should be addressed to William J. Joiner at wjoiner{at}health.ucsd.edu
Funding
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
R01 NS072431HHS | NIH | National Institute of General Medical Sciences (NIGMS)
R01 GM125080HHS | NIH | National Institute on Aging (NIA)
P30 AG062429
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