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Research Articles, Neurobiology of Disease

Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function

Jacob Ziontz, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker and William J. Jagust
Journal of Neuroscience 20 October 2021, 41 (42) 8839-8847; https://doi.org/10.1523/JNEUROSCI.0990-21.2021
Jacob Ziontz
1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, California 94720
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Jenna N. Adams
1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, California 94720
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Theresa M. Harrison
1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, California 94720
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Suzanne L. Baker
2Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720
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William J. Jagust
1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, California 94720
2Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0990-21.2021
PubMed 
34531286
Published By 
Society for Neuroscience
History 
  • Received May 10, 2021
  • Revision received August 27, 2021
  • Accepted August 30, 2021
  • First published September 16, 2021.
  • Version of record published October 20, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Jacob Ziontz1,
  2. Jenna N. Adams1,
  3. Theresa M. Harrison1,
  4. Suzanne L. Baker2, and
  5. William J. Jagust1,2
  1. 1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, California 94720
  2. 2Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720
View Full Text

Author contributions

  1. Author contributions: J.Z., J.N.A., T.M.H., and W.J.J. designed research; J.Z. and S.L.B. performed research; J.Z. analyzed data; J.Z. wrote the first draft of the paper; J.Z., J.N.A., T.M.H., S.L.B., and W.J.J. edited the paper; J.Z. and W.J.J. wrote the paper.

Disclosures

    • Received May 10, 2021.
    • Revision received August 27, 2021.
    • Accepted August 30, 2021.
  • This work was supported by National Institutes of Health Grants T32-NS095939 (to J.Z.), F31-AG062090 (to J.N.A.), F32-AG057107 (to T.M.H.), R01-AG062542 (to W.J.J.), and R01-AG034570 (to W.J.J.) and by the Rainwater Charitable Foundation (W.J.J.). Avid Radiopharmaceuticals enabled the use and the 18F-Flortaucipir tracer but did not provide direct funding and were not involved in data analysis or interpretation. We thank R. La Joie for assisting with selecting regions of interest and visualization of results.

  • W.J.J. consults for Genentech, Biogen, and Bioclinica. All other authors declare no competing financial interests.

  • Correspondence should be addressed to Jacob Ziontz at jacob_ziontz{at}berkeley.edu

Funding

  • HHS | National Institutes of Health (NIH)

    T32-NS095939; F31-AG062090; F32-AG057107; R01-AG034570
  • Rainwater Charitable Foundation

Other Version

  • previous version (September 16, 2021).
  • You are viewing the most recent version of this article.

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Sep 20211404076
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Total 2025144705292
Total614765181480
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The Journal of Neuroscience: 41 (42)
Journal of Neuroscience
Vol. 41, Issue 42
20 Oct 2021
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Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function
Jacob Ziontz, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Journal of Neuroscience 20 October 2021, 41 (42) 8839-8847; DOI: 10.1523/JNEUROSCI.0990-21.2021

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Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function
Jacob Ziontz, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Journal of Neuroscience 20 October 2021, 41 (42) 8839-8847; DOI: 10.1523/JNEUROSCI.0990-21.2021
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Keywords

  • episodic memory
  • functional connectivity
  • hippocampus
  • medial parietal
  • retrosplenial
  • tau

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