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Research Articles, Neurobiology of Disease

Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome

Eda Erata, Yudong Gao, Alicia M. Purkey, Erik J. Soderblom, James O. McNamara and Scott H. Soderling
Journal of Neuroscience 17 November 2021, 41 (46) 9633-9649; DOI: https://doi.org/10.1523/JNEUROSCI.0650-21.2021
Eda Erata
1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
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Yudong Gao
1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
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Alicia M. Purkey
1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
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Erik J. Soderblom
1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
3Proteomics and Metabolomics Shared Resource, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708
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James O. McNamara
2Department of Neurobiology, Duke University Medical School, Durham, North Carolina 27710
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Scott H. Soderling
1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
2Department of Neurobiology, Duke University Medical School, Durham, North Carolina 27710
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0650-21.2021
PubMed 
34580165
Published By 
Society for Neuroscience
History 
  • Received March 27, 2021
  • Revision received September 2, 2021
  • Accepted September 10, 2021
  • First published September 27, 2021.
  • Version of record published November 17, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Eda Erata1,
  2. Yudong Gao1,
  3. Alicia M. Purkey1,
  4. Erik J. Soderblom1,3,
  5. James O. McNamara2, and
  6. Scott H. Soderling1,2
  1. 1Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
  2. 2Department of Neurobiology, Duke University Medical School, Durham, North Carolina 27710
  3. 3Proteomics and Metabolomics Shared Resource, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708
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Author contributions

  1. Author contributions: E.E., Y.G., A.M.P., E.J.S., and S.H.S. designed research; E.E., Y.G., A.M.P., and E.J.S. performed research; E.E., Y.G., and J.O.M. analyzed data; E.E. wrote the first draft of the paper; E.E., Y.G., A.M.P., J.O.M., and S.H.S. edited the paper; E.E. and S.H.S. wrote the paper.

Disclosures

    • Received March 27, 2021.
    • Revision received September 2, 2021.
    • Accepted September 10, 2021.
  • S.H.S. and Y.G. have filed a patent application related to the HiUGE technology; the IP has been licensed to CasTag Biosciences. S.H.S. is a founder of CasTag Biosciences; Duke University as an institution holds equity in CasTag Biosciences. The remaining authors declare no competing financial interests.

  • This work was supported by National Institute of Mental Health Grant MH111684 to S.H.S.; and National Institute of Neurological Disorders and Stroke Grant NS097717 to J.O.M. We thank Fiona Porkka, Dr. Ramona Rodriguez, and Dr. William Christopher Wetsel (Duke Mouse Behavioral and Neuroendocrine Core Facility) for technical support and advice; Shataakshi Dube and Jamie Courtland for support on writing; Dr. Mohamad Abdul Mikati for advice on mouse EEGs; Dr. Valérie Mongrain for help on identifying vigilance states; and the rest of the S.H.S. laboratory members for helpful discussion.

  • Correspondence should be addressed to Scott H. Soderling at scott.soderling{at}duke.edu

Funding

  • NIMH

    MH111684
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS102456; NS097717

Other Version

  • previous version (September 27, 2021).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 41 (46)
Journal of Neuroscience
Vol. 41, Issue 46
17 Nov 2021
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Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome
Eda Erata, Yudong Gao, Alicia M. Purkey, Erik J. Soderblom, James O. McNamara, Scott H. Soderling
Journal of Neuroscience 17 November 2021, 41 (46) 9633-9649; DOI: 10.1523/JNEUROSCI.0650-21.2021

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Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome
Eda Erata, Yudong Gao, Alicia M. Purkey, Erik J. Soderblom, James O. McNamara, Scott H. Soderling
Journal of Neuroscience 17 November 2021, 41 (46) 9633-9649; DOI: 10.1523/JNEUROSCI.0650-21.2021
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Keywords

  • aphasia
  • Cnksr2
  • EEG
  • epilepsy
  • HiUGE
  • proteomics

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