Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome

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¹Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710
²Department of Neurobiology, Duke University Medical School, Durham, North Carolina 27710
³Proteomics and Metabolomics Shared Resource, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708

Author contributions: E.E., Y.G., A.M.P., E.J.S., and S.H.S. designed research; E.E., Y.G., A.M.P., and E.J.S. performed research; E.E., Y.G., and J.O.M. analyzed data; E.E. wrote the first draft of the paper; E.E., Y.G., A.M.P., J.O.M., and S.H.S. edited the paper; E.E. and S.H.S. wrote the paper.

S.H.S. and Y.G. have filed a patent application related to the HiUGE technology; the IP has been licensed to CasTag Biosciences. S.H.S. is a founder of CasTag Biosciences; Duke University as an institution holds equity in CasTag Biosciences. The remaining authors declare no competing financial interests.
This work was supported by National Institute of Mental Health Grant MH111684 to S.H.S.; and National Institute of Neurological Disorders and Stroke Grant NS097717 to J.O.M. We thank Fiona Porkka, Dr. Ramona Rodriguez, and Dr. William Christopher Wetsel (Duke Mouse Behavioral and Neuroendocrine Core Facility) for technical support and advice; Shataakshi Dube and Jamie Courtland for support on writing; Dr. Mohamad Abdul Mikati for advice on mouse EEGs; Dr. Valérie Mongrain for help on identifying vigilance states; and the rest of the S.H.S. laboratory members for helpful discussion.
Correspondence should be addressed to Scott H. Soderling at scott.soderling{at}duke.edu