Article Information
- Received September 30, 2020
- Revision received August 17, 2021
- Accepted September 21, 2021
- First published October 18, 2021.
- Version of record published December 8, 2021.
Author Information
- Rodrigo S. Chaves1,2,6,
- My Tran2,
- Andrew R. Holder2,
- Alexandra M. Balcer2,
- Andrea M. Dickey1,2,
- Elizabeth A. Roberts1,2,
- Brian G. Bober4,
- Edgar Gutierrez3,
- Brian P. Head7,8,
- Alex Groisman3,
- Lawrence S.B. Goldstein1,2,5,
- Angels Almenar-Queralt1,2, and
- Sameer B. Shah4,6,7
- 1Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093
- 2Sanford Consortium for Regenerative Medicine, La Jolla, California 92037
- 3Department of Physics, University of California, San Diego, California 92093
- 4Department of Bioengineering, University of California, San Diego, California 92093
- 5Department of Neurosciences, University of California, San Diego, California 92093
- 6Department of Orthopaedic Surgery, University of California, San Diego, California 92093
- 7Research Division, VA San Diego Healthcare System, San Diego, California 92161
- 8Department of Anesthesiology, University of California, San Diego, California 92093
Author contributions
Author contributions: R.S.C., A.A.-Q., and S.B.S. designed research; R.S.C., M.T., A.R.H., A.M.B., A.M.D., E.A.R., B.G.B., and E.G. performed research; R.S.C., M.T., A.R.H., A.M.B., A.M.D., E.A.R., B.G.B., B.P.H., A.G., A.A.-Q., and S.B.S. analyzed data; R.S.C. wrote the first draft of the paper; R.S.C., B.P.H., L.S.B.G., A.A.-Q., and S.B.S. edited the paper; R.S.C., A.A.-Q., and S.B.S. wrote the paper.
Disclosures
- Received September 30, 2020.
- Revision received August 17, 2021.
- Accepted September 21, 2021.
This work was supported by U.S. Department of Defense Peer Reviewed Alzheimer's Research Program W81XWH-19-1-0315 and W81XWH-15-1-0561 to S.B.S. and A.A.-Q.; and National Institutes of Health/National Institute on Aging 1RF1AG048083-01 and 5P50AG005131-34 to L.S.B.G. We thank Dr. Ivan Garcia-Bassets, Dr. Rik Van der Kant, Dr. Utpal Das, and members of the L.S.B.G. laboratory for helpful comments on data interpretation and presentation; and Dr. Elsa Molina and University of California-San Diego Stem Cell Genomics Core for the technical assistance using the Nanostring nCounter platform (supported by a CIRM Major Facilities Grant FA1-00607 to the Sanford Consortium for Regenerative Medicine).
The authors declare no competing financial interests.
- Correspondence should be addressed to Sameer B. Shah at sbshah{at}health.ucsd.edu or Angels Almenar-Queralt at aalmenar{at}health.ucsd.edu
Funding
DOD | United States Army | MEDCOM | Congressionally Directed Medical Research Programs (CDMRP)
W81XWH-15-1-0561; W81XWH-19-1-0315NIH/NIA
1RF1AG048083-01; 5P50AG005131-34
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