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Symposium/Mini-Symposium

The Logic of Developing Neocortical Circuits in Health and Disease

Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco García, Jessica A. Cardin, Bradley Voytek and Alysson R. Muotri
Journal of Neuroscience 3 February 2021, 41 (5) 813-822; DOI: https://doi.org/10.1523/JNEUROSCI.1655-20.2020
Ileana L. Hanganu-Opatz
1Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany
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Simon J. B. Butt
2Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, OX1 3PT, United Kingdom
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Simon Hippenmeyer
3Institute of Science and Technology Austria, Klosterneuburg, 3400, Austria
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Natalia V. De Marco García
4Center for Neurogenetics, Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10021
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Jessica A. Cardin
5Department of Neuroscience and Kavli Institute for Neuroscience, Yale University, New Haven, Connecticut 06520
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Bradley Voytek
6University of California San Diego, Department of Cognitive Science, Halıcıoğlu Data Science Institute, Neurosciences Graduate Program, La Jolla, California 92093
7University of California San Diego, Kavli Institute for Brain and Mind, La Jolla, California 92093
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Alysson R. Muotri
7University of California San Diego, Kavli Institute for Brain and Mind, La Jolla, California 92093
8University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Center for Academic Research and Training in Anthropogeny, La Jolla, California 92037
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Abstract

The sensory and cognitive abilities of the mammalian neocortex are underpinned by intricate columnar and laminar circuits formed from an array of diverse neuronal populations. One approach to determining how interactions between these circuit components give rise to complex behavior is to investigate the rules by which cortical circuits are formed and acquire functionality during development. This review summarizes recent research on the development of the neocortex, from genetic determination in neural stem cells through to the dynamic role that specific neuronal populations play in the earliest circuits of neocortex, and how they contribute to emergent function and cognition. While many of these endeavors take advantage of model systems, consideration will also be given to advances in our understanding of activity in nascent human circuits. Such cross-species perspective is imperative when investigating the mechanisms underlying the dysfunction of early neocortical circuits in neurodevelopmental disorders, so that one can identify targets amenable to therapeutic intervention.

  • brain organoids
  • development
  • neuronal networks
  • oscillations
  • sensory cortices
  • prefrontal cortex

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The Journal of Neuroscience: 41 (5)
Journal of Neuroscience
Vol. 41, Issue 5
3 Feb 2021
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The Logic of Developing Neocortical Circuits in Health and Disease
Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco García, Jessica A. Cardin, Bradley Voytek, Alysson R. Muotri
Journal of Neuroscience 3 February 2021, 41 (5) 813-822; DOI: 10.1523/JNEUROSCI.1655-20.2020

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The Logic of Developing Neocortical Circuits in Health and Disease
Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco García, Jessica A. Cardin, Bradley Voytek, Alysson R. Muotri
Journal of Neuroscience 3 February 2021, 41 (5) 813-822; DOI: 10.1523/JNEUROSCI.1655-20.2020
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Keywords

  • brain organoids
  • development
  • neuronal networks
  • oscillations
  • sensory cortices
  • prefrontal cortex

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