Focal Sleep Spindle Deficits Reveal Focal Thalamocortical Dysfunction and Predict Cognitive Deficits in Sleep Activated Developmental Epilepsy

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¹Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215
²Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114
³Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114
⁴Harvard Medical School, Boston, Massachusetts 02115
⁵Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215
⁶Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129

Author contributions: M.A.K., S.M.S., D.C., L.M.O., A.K.M., B.C.E., and C.J.C. performed research; M.A.K., D.C., E.R.S., U.T.E., and C.J.C. analyzed data; M.A.K. and C.J.C. wrote the first draft of the paper; M.A.K., S.M.S., D.C., L.M.O., E.R.S., A.K.M., B.C.E., R.S., D.S.M., and C.J.C. edited the paper; M.A.K. and C.J.C. wrote the paper; J.J., M.B.W., R.S., and D.S.M. contributed unpublished reagents/analytic tools; C.J.C. designed research.

M.A.K. was supported by National Science Foundation DMS Award 1451384. E.R.S. was supported by National Science Foundation GRFP. C.J.C. was supported by National Institutes of Health K23 Award NS092923. C.J.C., M.A.K., and D.S.M. were supported by National Institutes of Health National Institute of Neurological Disorders and Stroke R01NS115868.
The authors declare no competing financial interests.
Correspondence should be addressed to Catherine J. Chu at cjchu{at}mgh.harvard.edu

National Science Foundation (NSF)
1451384; GRFP
Office of Extramural Research, National Institutes of Health (OER)
NS092923
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
R01NS115868