This image shows the patterned degeneration seen in coronal cerebellums of 10-month-old mice that have lost Ankyrin-R in the CBS. Purkinje neurons are labeled for Calbindin (green) and Neurofilament-H (red), and nuclei are in blue (Hoechst). For more information, see the article by Stevens et al. (pages 2–15). Cover image: Sharon R. Stevens and Matthew N. Rasband.