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Featured ArticleResearch Articles, Cellular/Molecular

Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals

Shankar Ramachandran, Shelagh Rodgriguez, Mariana Potcoava and Simon Alford
Journal of Neuroscience 23 March 2022, 42 (12) 2385-2403; DOI: https://doi.org/10.1523/JNEUROSCI.2207-21.2022
Shankar Ramachandran
2Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607-4306
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Shelagh Rodgriguez
1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308
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Mariana Potcoava
1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308
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Simon Alford
1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2207-21.2022
PubMed 
35063999
Published By 
Society for Neuroscience
History 
  • Received November 5, 2021
  • Revision received December 22, 2021
  • Accepted January 6, 2022
  • First published January 21, 2022.
  • Version of record published March 23, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Shankar Ramachandran2,
  2. Shelagh Rodgriguez1,
  3. Mariana Potcoava1, and
  4. Simon Alford1
  1. 1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612-7308
  2. 2Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607-4306
  • S. Ramachandran's present address: Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-4231.

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Author contributions

  1. Author contributions: S.Ra. and S.A. designed research; S.Ra., S.Ro., M.P., and S.A. performed research; S.Ra., S.Ro., M.P., and S.A. analyzed data; S.Ra., S.Ro., M.P., and S.A. edited the paper; S.Ra. and S.A. wrote the paper.

  • S. Ramachandran's present address: Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-4231.

Disclosures

    • Received November 5, 2021.
    • Revision received December 22, 2021.
    • Accepted January 6, 2022.
  • This work was supported by National Institutes of Health Grants R01 MH084874 and R01 NS052699 (to S.A.). We thank Dr. Janet Richmond for helpful discussions and resources throughout the course of this study and Dr. Jonathan Art for feedback on this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Simon Alford at sta{at}uic.edu

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01 MH084874
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01 NS052699

Other Version

  • previous version (January 21, 2022).
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The Journal of Neuroscience: 42 (12)
Journal of Neuroscience
Vol. 42, Issue 12
23 Mar 2022
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Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals
Shankar Ramachandran, Shelagh Rodgriguez, Mariana Potcoava, Simon Alford
Journal of Neuroscience 23 March 2022, 42 (12) 2385-2403; DOI: 10.1523/JNEUROSCI.2207-21.2022

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Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals
Shankar Ramachandran, Shelagh Rodgriguez, Mariana Potcoava, Simon Alford
Journal of Neuroscience 23 March 2022, 42 (12) 2385-2403; DOI: 10.1523/JNEUROSCI.2207-21.2022
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Keywords

  • active zone
  • nanodomain
  • neurotransmitter release
  • presynaptic
  • synaptic vesicle fusion
  • voltage-gated calcium channel

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