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Featured ArticleResearch Articles, Cellular/Molecular

Fibroblastic SMOC2 Suppresses Mechanical Nociception by Inhibiting Coupled Activation of Primary Sensory Neurons

Shuo Zhang, Bing Cai, Zhen Li, Kaikai Wang, Lan Bao, Changlin Li and Xu Zhang
Journal of Neuroscience 18 May 2022, 42 (20) 4069-4086; DOI: https://doi.org/10.1523/JNEUROSCI.2132-21.2022
Shuo Zhang
1Institute of Neuroscience and State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
2School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
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Bing Cai
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
4Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China
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Zhen Li
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
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Kaikai Wang
1Institute of Neuroscience and State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
2School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
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Lan Bao
2School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
5State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China
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Changlin Li
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
4Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China
6Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518060, China
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Xu Zhang
1Institute of Neuroscience and State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
2School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
4Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2132-21.2022
PubMed 
35437277
Published By 
Society for Neuroscience
History 
  • Received October 26, 2021
  • Revision received April 3, 2022
  • Accepted April 6, 2022
  • First published April 18, 2022.
  • Version of record published May 18, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Shuo Zhang1,2,3,
  2. Bing Cai3,4,
  3. Zhen Li3,
  4. Kaikai Wang1,2,3,
  5. Lan Bao2,5,
  6. Changlin Li3,4,6, and
  7. Xu Zhang1,2,3,4
  1. 1Institute of Neuroscience and State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
  2. 2School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
  3. 3Research Unit of Pain Medicine, Chinese Academy of Medical Sciences; and SIMR Joint Lab of Drug Innovation, Shanghai Advanced Research Institute, Chinese Academy of Sciences; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, 201210, China
  4. 4Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China
  5. 5State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China
  6. 6Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518060, China
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Author contributions

  1. Author contributions: X.Z., S.Z., C.L., and L.B. designed research; S.Z., L.B., C.L., and X.Z. wrote the paper; S.Z., B.C., Z.L., and K.W. performed research; S.Z., B.C., Z.L., and K.W. analyzed data.

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Disclosures

    • Received October 26, 2021.
    • Revision received April 3, 2022.
    • Accepted April 6, 2022.
  • This work was supported by National Natural Science Foundation of China 32071001, 32192413, 31671094, and 32030050; Chinese Academy of Sciences QYZDYSSW-SMC007; Special Fund for Science-Technology Innovation Strategy of Guangdong Province 2021B0909050004; Science and Technology Commission of Shanghai Municipality 18JC1420301; Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences 2019-I2M-5-082; and Shenzhen Sanming Project.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Xu Zhang at zhangx{at}sari.ac.cn or Changlin Li at licl{at}gdiist.cn

Funding

  • National Natural Science Foundation of China (NSFC)

    32071001; 31630033
  • Chinese Academy of Sciences (CAS)

    QYZDYSSW-SMC007
  • the Strategic Priority Research Program of the Chinese Academy of Sciences

    XDB39050100
  • Science and Technology Commission of Shanghai Municipality (STCSM)

    18JC1420301
  • Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences

    2019-I2M-5-082

Other Version

  • previous version (April 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (20)
Journal of Neuroscience
Vol. 42, Issue 20
18 May 2022
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Fibroblastic SMOC2 Suppresses Mechanical Nociception by Inhibiting Coupled Activation of Primary Sensory Neurons
Shuo Zhang, Bing Cai, Zhen Li, Kaikai Wang, Lan Bao, Changlin Li, Xu Zhang
Journal of Neuroscience 18 May 2022, 42 (20) 4069-4086; DOI: 10.1523/JNEUROSCI.2132-21.2022

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Fibroblastic SMOC2 Suppresses Mechanical Nociception by Inhibiting Coupled Activation of Primary Sensory Neurons
Shuo Zhang, Bing Cai, Zhen Li, Kaikai Wang, Lan Bao, Changlin Li, Xu Zhang
Journal of Neuroscience 18 May 2022, 42 (20) 4069-4086; DOI: 10.1523/JNEUROSCI.2132-21.2022
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Keywords

  • DRG
  • fibroblast
  • mechanical nociception
  • SMOC2

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