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Cover ArticleFeatured ArticleResearch Articles, Cellular/Molecular

Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1

Colten K. Lankford, Yumiko Umino, Deepak Poria, Vladimir Kefalov, Eduardo Solessio and Sheila A. Baker
Journal of Neuroscience 25 May 2022, 42 (21) 4231-4249; DOI: https://doi.org/10.1523/JNEUROSCI.2271-21.2022
Colten K. Lankford
1Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa 52242
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Yumiko Umino
2Center for Vision Research, Department of Ophthalmology and Visual Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210
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Deepak Poria
3Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California 92697
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Vladimir Kefalov
3Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California 92697
4Department of Physiology and Biophysics, University of California, Irvine, California 92697
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Eduardo Solessio
2Center for Vision Research, Department of Ophthalmology and Visual Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210
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Sheila A. Baker
1Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa 52242
5Department of Ophthalmology and Visual Sciences and Institute for Vision Research, University of Iowa, Iowa City, Iowa 52242
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2271-21.2022
PubMed 
35437278
Published By 
Society for Neuroscience
History 
  • Received November 16, 2021
  • Revision received April 1, 2022
  • Accepted April 7, 2022
  • First published April 18, 2022.
  • Version of record published May 25, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Colten K. Lankford1,
  2. Yumiko Umino2,
  3. Deepak Poria3,
  4. Vladimir Kefalov3,4,
  5. Eduardo Solessio2, and
  6. Sheila A. Baker1,5
  1. 1Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa 52242
  2. 2Center for Vision Research, Department of Ophthalmology and Visual Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210
  3. 3Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California 92697
  4. 4Department of Physiology and Biophysics, University of California, Irvine, California 92697
  5. 5Department of Ophthalmology and Visual Sciences and Institute for Vision Research, University of Iowa, Iowa City, Iowa 52242
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Author contributions

  1. Author contributions: C.K.L., Y.U., V.K., E.S., and S.A.B. designed research; C.K.L., Y.U., and D.P. performed research; C.K.L., D.P., V.K., E.S., and S.A.B. analyzed data; C.K.L. wrote the first draft of the paper; C.K.L., Y.U., D.P., V.K., E.S., and S.A.B. edited the paper; C.K.L. and S.A.B. wrote the paper.

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Disclosures

    • Received November 16, 2021.
    • Revision received April 1, 2022.
    • Accepted April 7, 2022.
  • This work was supported by National Eye Institute Grants R01 EY020542 (to S.A.B.), R01s EY027387 and EY030912 (to V.K.), and R01 EY026216 (to E.S.). This work was also supported by unrestricted grants from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences at State University of New York Upstate Medical University and the Department of Ophthalmology at University of California, Irvine.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Sheila A. Baker at sheila-baker{at}uiowa.edu

Funding

  • HHS | NIH | National Eye Institute (NEI)

    EY020542; EY027387; EY030912; EY026216

Other Version

  • previous version (April 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (21)
Journal of Neuroscience
Vol. 42, Issue 21
25 May 2022
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Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1
Colten K. Lankford, Yumiko Umino, Deepak Poria, Vladimir Kefalov, Eduardo Solessio, Sheila A. Baker
Journal of Neuroscience 25 May 2022, 42 (21) 4231-4249; DOI: 10.1523/JNEUROSCI.2271-21.2022

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Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1
Colten K. Lankford, Yumiko Umino, Deepak Poria, Vladimir Kefalov, Eduardo Solessio, Sheila A. Baker
Journal of Neuroscience 25 May 2022, 42 (21) 4231-4249; DOI: 10.1523/JNEUROSCI.2271-21.2022
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Keywords

  • cone
  • ERG
  • HCN1
  • light adaptation
  • photovoltage
  • rod

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