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Research Articles, Systems/Circuits

Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses

Debanjan Dasgupta, Tom P. A. Warner, Andrew Erskine and Andreas T. Schaefer
Journal of Neuroscience 25 May 2022, 42 (21) 4278-4296; DOI: https://doi.org/10.1523/JNEUROSCI.1422-21.2022
Debanjan Dasgupta
1Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London NW1 1AT, United Kingdom
2Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
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Tom P. A. Warner
1Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London NW1 1AT, United Kingdom
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Andrew Erskine
1Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London NW1 1AT, United Kingdom
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Andreas T. Schaefer
1Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London NW1 1AT, United Kingdom
2Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1422-21.2022
PubMed 
35440491
Published By 
Society for Neuroscience
History 
  • Received July 11, 2021
  • Revision received March 24, 2022
  • Accepted March 29, 2022
  • First published April 19, 2022.
  • Version of record published May 25, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Debanjan Dasgupta1,2,
  2. Tom P. A. Warner1,
  3. Andrew Erskine1, and
  4. Andreas T. Schaefer1,2
  1. 1Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London NW1 1AT, United Kingdom
  2. 2Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
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Author contributions

  1. Author contributions: D.D. and A.T.S. designed research; D.D. and T.P.A.W. performed research; A.E. contributed unpublished reagents/analytic tools; D.D. and T.P.A.W. analyzed data; D.D. and A.T.S. wrote the paper.

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Disclosures

    • Received July 11, 2021.
    • Revision received March 24, 2022.
    • Accepted March 29, 2022.
  • This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research United Kingdom (UK; Grant FC001153); the UK Medical Research Council (Grant FC001153); the Wellcome Trust (Grant FC001153); the UK Medical Research Council (Grant reference MC_UP_1202/5); Wellcome Trust Investigator Grant 110174/Z/15/Z (to A.T.S.); and the National Science Foundation/Canadian Institutes of Health Research/German Research Foundation/ Fonds de Recherche du Québec/UK Research and Innovation–Medical Research Council Next Generation Networks for Neuroscience Program (Award No. 2014217). We thank the animal facilities at the National Institute for Medical Research and the Francis Crick Institute for animal care and technical assistance, the mechanical and electronic workshop (Alan Ling, Adam Hurst, Martyn Stopps), Dr. Swagata Ghatak and members of the Sensory Circuits and Neurotechnology Laboratory for comments on earlier versions of the manuscript, and Dr. Rebecca Jordan for help during the initial days of whole-cell recordings.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Debanjan Dasgupta at d.dasgupta{at}ucl.ac.uk or Andreas T. Schaefer at Andreas.Schaefer{at}crick.ac.uk

Funding

  • Francis Crick Institute (FCI)

  • Wellcome

    FC001153 & 110174/Z/15/Z (ATS)
  • UKRI | Medical Research Council (MRC)

    FC001153
  • Cancer Research UK (CRUK)

    FC001153

Other Version

  • previous version (April 19, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (21)
Journal of Neuroscience
Vol. 42, Issue 21
25 May 2022
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Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses
Debanjan Dasgupta, Tom P. A. Warner, Andrew Erskine, Andreas T. Schaefer
Journal of Neuroscience 25 May 2022, 42 (21) 4278-4296; DOI: 10.1523/JNEUROSCI.1422-21.2022

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Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses
Debanjan Dasgupta, Tom P. A. Warner, Andrew Erskine, Andreas T. Schaefer
Journal of Neuroscience 25 May 2022, 42 (21) 4278-4296; DOI: 10.1523/JNEUROSCI.1422-21.2022
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Keywords

  • frequency coupling
  • in vivo electrophysiology
  • inhibition
  • olfaction
  • olfactory bulb
  • temporal structure in odor

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