Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Research Articles, Neurobiology of Disease

Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing

Úrsula Pérez-Ramírez, Víctor J. López-Madrona, Andrés Pérez-Segura, Vicente Pallarés, Andrea Moreno, Roberto Ciccocioppo, Petri Hyytiä, Wolfgang H. Sommer, David Moratal and Santiago Canals
Journal of Neuroscience 25 May 2022, 42 (21) 4401-4413; DOI: https://doi.org/10.1523/JNEUROSCI.0389-21.2022
Úrsula Pérez-Ramírez
1Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, E-46022 Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Víctor J. López-Madrona
2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Víctor J. López-Madrona
Andrés Pérez-Segura
2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vicente Pallarés
2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrea Moreno
2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roberto Ciccocioppo
3School of Pharmacy, University of Camerino, 62032 Camerino, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Petri Hyytiä
4Department of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wolfgang H. Sommer
5Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Wolfgang H. Sommer
David Moratal
1Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, E-46022 Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Santiago Canals
2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Santiago Canals
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0389-21.2022
PubMed 
35437279
Published By 
Society for Neuroscience
History 
  • Received February 21, 2021
  • Revision received March 25, 2022
  • Accepted March 30, 2022
  • First published April 18, 2022.
  • Version of record published May 25, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Úrsula Pérez-Ramírez1,
  2. Víctor J. López-Madrona2,
  3. Andrés Pérez-Segura2,
  4. Vicente Pallarés2,
  5. Andrea Moreno2,
  6. Roberto Ciccocioppo3,
  7. Petri Hyytiä4,
  8. Wolfgang H. Sommer5,
  9. David Moratal1, and
  10. Santiago Canals2
  1. 1Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, E-46022 Valencia, Spain
  2. 2Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain
  3. 3School of Pharmacy, University of Camerino, 62032 Camerino, Italy
  4. 4Department of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
  5. 5Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany
  • V.J. López-Madrona's present address: Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France.

  • A. Moreno's present address: Danish Research Institute of Translational Neuroscience (DANDRITE), Aarhus University, 8000 Aarhus, Denmark.

View Full Text

Author contributions

  1. Author contributions: Ú.P.-R., V.J.L.-M., V.P., R.C., P.H., W.H.S., D.M., and S.C. designed research; Ú.P.-R., A.M. and P.H. performed research; A.M. and R.C. contributed unpublished reagents/analytic tools; Ú.P.-R., V.J.L.-M., A.P.-S., V.P., D.M., and S.C. analyzed data; Ú.P.-R., V.J.L.-M., D.M., and S.C. wrote the paper.

  • V.J. López-Madrona's present address: Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France.

  • A. Moreno's present address: Danish Research Institute of Translational Neuroscience (DANDRITE), Aarhus University, 8000 Aarhus, Denmark.

Disclosures

    • Received February 21, 2021.
    • Revision received March 25, 2022.
    • Accepted March 30, 2022.
  • This research was supported by funding from the European Union Horizon 2020 research and innovation program under Grant 668863 (SyBil-AA); the ERA-Net NEURON framework with grants given to the project “Translational Neuroimaging in Alcoholism” (TRANSALC) by the Academy of Finland (Grant TRANSALC 01EW1112), the Bundesministerium für Bildung und Forschung (Grant FKZ01EW1112), and the Spanish Ministerio de Ciencia e Innovación (Grant PIM2010ERN-00679). S.C. and D.M. were funded by the Spanish Ministerio de Economía y Competitividad (MINECO) cofinanced by the European Regional Development Fund (ERDF) under Grants BFU2015-64380-C2-1-R and BFU2015-64380-C2-2-R, and the Generalitat Valenciana Government through the Prometeo Program (Grant PROMETEO/2019/015). S.C. was further supported by the Spanish Agency of Research (AEI) and ERDF under Grant PGC2018-101055-B-I00 and the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad (Grant 2017I065). Ú.P.-R. was supported by Grant FPU13/03537 and research stay internship EST15/00516 from the Spanish Ministerio de Educación, Cultura y Deporte (MECD). Further funding was obtained from the Spanish State Research Agency through the Severo Ochoa Program for Centres of Excellence in R&D (Grant SEV- 2017-0723). W.H.S. was further supported by the Deutsche Forschungsgemeinschaft (Center Grant TRR265-B08). We thank Eugene Duff and Stephen Smith for comments on a previous version of this manuscript. We also thank Begoña Fernández for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to David Moratal at dmoratal{at}eln.upv.es or Santiago Canals at scanals{at}umh.es

Other Version

  • previous version (April 18, 2022).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2022-08-12
to
E.g., 2022-08-12

Article usage: April 2022 to August 2022

AbstractFullPdf
Apr 20221721043
May 2022115811569
Jun 20223812619
Jul 20221711718
Aug 20224822
Total 20223479160151
Total3479160151
Back to top

In this issue

The Journal of Neuroscience: 42 (21)
Journal of Neuroscience
Vol. 42, Issue 21
25 May 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
Úrsula Pérez-Ramírez, Víctor J. López-Madrona, Andrés Pérez-Segura, Vicente Pallarés, Andrea Moreno, Roberto Ciccocioppo, Petri Hyytiä, Wolfgang H. Sommer, David Moratal, Santiago Canals
Journal of Neuroscience 25 May 2022, 42 (21) 4401-4413; DOI: 10.1523/JNEUROSCI.0389-21.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
Úrsula Pérez-Ramírez, Víctor J. López-Madrona, Andrés Pérez-Segura, Vicente Pallarés, Andrea Moreno, Roberto Ciccocioppo, Petri Hyytiä, Wolfgang H. Sommer, David Moratal, Santiago Canals
Journal of Neuroscience 25 May 2022, 42 (21) 4401-4413; DOI: 10.1523/JNEUROSCI.0389-21.2022
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • alcohol
  • allostasis
  • AUD
  • fMRI
  • MEMRI
  • network

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8
  • Maturational Indices of the Cognitive Control Network Are Associated with Inhibitory Control in Early Childhood
  • The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons
Show more Research Articles

Neurobiology of Disease

  • Altered Cortical Trigeminal Fields Excitability by Spreading Depolarization Revealed with in Vivo Functional Ultrasound Imaging Combined with Electrophysiology
  • Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer’s mouse models
  • Shared and distinct functional effects of patient-specific Tbr1 mutations on cortical development
Show more Neurobiology of Disease
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2022 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.