Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Featured ArticleResearch Articles, Cellular/Molecular

Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation

Chan Choo Yap, Laura Digilio, Lloyd P. McMahon, Tuanlao Wang and Bettina Winckler
Journal of Neuroscience 1 June 2022, 42 (22) 4415-4434; DOI: https://doi.org/10.1523/JNEUROSCI.2530-21.2022
Chan Choo Yap
1Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Chan Choo Yap
Laura Digilio
1Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lloyd P. McMahon
1Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tuanlao Wang
2School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian Province 361005, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bettina Winckler
1Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bettina Winckler
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2530-21.2022
PubMed 
35474277
Published By 
Society for Neuroscience
History 
  • Received December 23, 2021
  • Revision received March 30, 2022
  • Accepted April 15, 2022
  • First published April 26, 2022.
  • Version of record published June 1, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Chan Choo Yap1,
  2. Laura Digilio1,
  3. Lloyd P. McMahon1,
  4. Tuanlao Wang2, and
  5. Bettina Winckler1
  1. 1Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908
  2. 2School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian Province 361005, China
View Full Text

Author contributions

  1. Author contributions: C.C.Y. and B.W. designed research; C.C.Y., L.D., and L.P.M. performed research; C.C.Y., L.D., and L.P.M. analyzed data; C.C.Y., L.D., and L.P.M. edited the paper; T.W. contributed unpublished reagents/analytic tools; B.W. wrote the first draft of the paper.

View Full Text

Disclosures

    • Received December 23, 2021.
    • Revision received March 30, 2022.
    • Accepted April 15, 2022.
  • This work was supported by National Institutes of Health Grant R01NS083378 to B.W. We thank Dr. Kevin Pfister (University of Virginia) for reagents and advice; and Ashley Mason and Ryan Mulligan for critical reading of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Bettina Winckler at bwinckler{at}virginia.edu or Chan Choo Yap at cy5x{at}virginia.edu

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS081674

Other Version

  • previous version (April 26, 2022).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2022-08-13
to
E.g., 2022-08-13

Article usage: April 2022 to August 2022

AbstractFullPdf
Apr 2022534032
May 2022599197
Jun 2022157020798
Jul 20222275049
Aug 202249106
Total 20222979268282
Total2979268282
Back to top

In this issue

The Journal of Neuroscience: 42 (22)
Journal of Neuroscience
Vol. 42, Issue 22
1 Jun 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation
Chan Choo Yap, Laura Digilio, Lloyd P. McMahon, Tuanlao Wang, Bettina Winckler
Journal of Neuroscience 1 June 2022, 42 (22) 4415-4434; DOI: 10.1523/JNEUROSCI.2530-21.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation
Chan Choo Yap, Laura Digilio, Lloyd P. McMahon, Tuanlao Wang, Bettina Winckler
Journal of Neuroscience 1 June 2022, 42 (22) 4415-4434; DOI: 10.1523/JNEUROSCI.2530-21.2022
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • degradation
  • dendrite
  • dynein
  • lysosome
  • Rab7
  • RILP

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8
  • Maturational Indices of the Cognitive Control Network Are Associated with Inhibitory Control in Early Childhood
  • The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons
Show more Research Articles

Cellular/Molecular

  • Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8
  • Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling
  • Drosophila Homolog of the Human Carpenter Syndrome Linked Gene, MEGF8, is Required for Synapse Development and Function
Show more Cellular/Molecular
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2022 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.