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Research Articles, Neurobiology of Disease

Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF

Guendalina Bastioli, Jennifer C. Arnold, Maria Mancini, Adam C. Mar, Begoña Gamallo-Lana, Khalil Saadipour, Moses V. Chao and Margaret E. Rice
Journal of Neuroscience 8 June 2022, 42 (23) 4725-4736; DOI: https://doi.org/10.1523/JNEUROSCI.2273-21.2022
Guendalina Bastioli
1Departments of Neuroscience and Physiology and
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Jennifer C. Arnold
2Neurosurgery, New York University Grossman School of Medicine, New York, New York 10016
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Maria Mancini
1Departments of Neuroscience and Physiology and
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Adam C. Mar
1Departments of Neuroscience and Physiology and
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Begoña Gamallo-Lana
1Departments of Neuroscience and Physiology and
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Khalil Saadipour
3Skirball Institute of Biomolecular Medicine, New York University Grossman School of Medicine, New York, New York 10016
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Moses V. Chao
3Skirball Institute of Biomolecular Medicine, New York University Grossman School of Medicine, New York, New York 10016
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Margaret E. Rice
1Departments of Neuroscience and Physiology and
2Neurosurgery, New York University Grossman School of Medicine, New York, New York 10016
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2273-21.2022
PubMed 
35577554
Published By 
Society for Neuroscience
History 
  • Received November 14, 2021
  • Revision received March 9, 2022
  • Accepted April 10, 2022
  • First published May 16, 2022.
  • Version of record published June 8, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Guendalina Bastioli1,
  2. Jennifer C. Arnold2,
  3. Maria Mancini1,
  4. Adam C. Mar1,
  5. Begoña Gamallo-Lana1,
  6. Khalil Saadipour3,
  7. Moses V. Chao3, and
  8. Margaret E. Rice1,2
  1. 1Departments of Neuroscience and Physiology and
  2. 2Neurosurgery, New York University Grossman School of Medicine, New York, New York 10016
  3. 3Skirball Institute of Biomolecular Medicine, New York University Grossman School of Medicine, New York, New York 10016
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Author contributions

  1. Author contributions: M.E.R., G.B., J.C.A., M.M., A.C.M., K.S., and M.V.C. designed research; G.B., J.C.A., M.M., A.C.M., B.G.-L., and K.S. performed research; A.C.M. contributed unpublished analytic tools; G.B., J.C.A., M.M., A.C.M., B.G.-L., K.S., and M.E.R. analyzed data; G.B. and M.E.R. wrote the paper.

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Disclosures

    • Received November 14, 2021.
    • Revision received March 9, 2022.
    • Accepted April 10, 2022.
  • This work was supported by the Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders (G.B., J.C.A., M.M., and M.E.R.), and by National Institutes of Health Grants R01 DA050165 (M.E.R.), R01 MH110136 (M.V.C.), and U19 NS107616 (M.V.C. and A.C.M.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Margaret E. Rice at margaret.rice{at}nyu.edu

Funding

  • Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders

    n/a
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    R01 DA050165
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    U19 NS107616
  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01 MH110136

Other Version

  • previous version (May 16, 2022).
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The Journal of Neuroscience: 42 (23)
Journal of Neuroscience
Vol. 42, Issue 23
8 Jun 2022
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Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF
Guendalina Bastioli, Jennifer C. Arnold, Maria Mancini, Adam C. Mar, Begoña Gamallo-Lana, Khalil Saadipour, Moses V. Chao, Margaret E. Rice
Journal of Neuroscience 8 June 2022, 42 (23) 4725-4736; DOI: 10.1523/JNEUROSCI.2273-21.2022

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Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF
Guendalina Bastioli, Jennifer C. Arnold, Maria Mancini, Adam C. Mar, Begoña Gamallo-Lana, Khalil Saadipour, Moses V. Chao, Margaret E. Rice
Journal of Neuroscience 8 June 2022, 42 (23) 4725-4736; DOI: 10.1523/JNEUROSCI.2273-21.2022
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Keywords

  • brain slices
  • fast-scan cyclic voltammetry
  • nAChRs
  • nucleus accumbens
  • Parkinson's disease
  • running wheel

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