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Cover ArticleResearch Articles, Neurobiology of Disease

Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia

Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe and Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: https://doi.org/10.1523/JNEUROSCI.0543-22.2022
Elizabeth L. Steuer
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Lisa J. Kemper
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Chris J.W. Hlynialuk
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Kailee Leinonen-Wright
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Michelle L. Montonye
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Ian P. Lapcinski
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Colleen L. Forster
1N. Bud Grossman Center for Memory Research and Care
3UMN Academic Health Center Biological Materials Procurement Network, University of Minnesota, Minneapolis, Minnesota 55455
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  • ORCID record for Colleen L. Forster
Karen H. Ashe
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
4Geriatric Research, Education, and Clinical Centers, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417
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Peng Liu
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0543-22.2022
PubMed 
35508385
Published By 
Society for Neuroscience
History 
  • Received March 16, 2022
  • Revision received April 22, 2022
  • Accepted April 28, 2022
  • First published May 4, 2022.
  • Version of record published June 8, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Elizabeth L. Steuer1,2,*,
  2. Lisa J. Kemper1,2,*,
  3. Chris J.W. Hlynialuk1,2,
  4. Kailee Leinonen-Wright1,2,
  5. Michelle L. Montonye1,2,
  6. Ian P. Lapcinski1,2,
  7. Colleen L. Forster1,3,
  8. Karen H. Ashe1,2,4, and
  9. Peng Liu1,2
  1. 1N. Bud Grossman Center for Memory Research and Care
  2. 2Department of Neurology
  3. 3UMN Academic Health Center Biological Materials Procurement Network, University of Minnesota, Minneapolis, Minnesota 55455
  4. 4Geriatric Research, Education, and Clinical Centers, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417
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Author contributions

  1. Author contributions: E.L.S., L.J.K., C.J.W.H., K.L.-W., K.H.A., and P.L. designed research; E.L.S., L.J.K., C.J.W.H., K.L.-W., M.L.M., I.P.L., C.L.F., and P.L. performed research; E.L.S., L.J.K., C.J.W.H., K.L.-W., M.L.M., K.H.A., and P.L. analyzed data; E.L.S. and P.L. wrote the first draft of the paper; E.L.S., L.J.K., K.L.-W., K.H.A., and P.L. edited the paper; E.L.S. and P.L. wrote the paper.

  2. ↵*E.L.S. and L.J.K. contributed equally to this work.

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Disclosures

    • Received March 16, 2022.
    • Revision received April 22, 2022.
    • Accepted April 28, 2022.
  • This work was supported by the National Institutes of Health National Research Service Award F31 AG057104-01, Alzheimer's Association Zenith Award 453589, and National Institutes of Health/National Institute of Neurological Disorders and Stroke R01 NS079374-02. Imaging of tissue specimens was performed at the University Imaging Centers at the University of Minnesota (RRID:SCR_020997). We thank Dr. Mark Sanders for guidance in confocal microscopy and data collection; and Dr. Michael Koob and Kellie Benzow (University of Minnesota, Twin Cities, MN) for generating the responder T1, T2, and T3 mouse lines. Dr. Michael Koob and Kellie Benzow were not involved in the characterization of rT1, rT2, and rT3 mice presented in this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Peng Liu at liuxx726{at}umn.edu

Funding

  • HHS | National Institutes of Health (NIH)

    F31 AG057104-01
  • Alzheimer's Association Zenith Award

    453589
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01 NS079374-02

Other Version

  • previous version (May 04, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (23)
Journal of Neuroscience
Vol. 42, Issue 23
8 Jun 2022
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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022

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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022
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Keywords

  • cognition
  • dementia
  • microtubule-associated protein tau
  • mouse model
  • neurodegeneration
  • synapse

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