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Cover ArticleResearch Articles, Neurobiology of Disease

Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia

Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe and Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; https://doi.org/10.1523/JNEUROSCI.0543-22.2022
Elizabeth L. Steuer
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Lisa J. Kemper
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Chris J.W. Hlynialuk
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Kailee Leinonen-Wright
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Michelle L. Montonye
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Ian P. Lapcinski
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Colleen L. Forster
1N. Bud Grossman Center for Memory Research and Care
3UMN Academic Health Center Biological Materials Procurement Network, University of Minnesota, Minneapolis, Minnesota 55455
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  • ORCID record for Colleen L. Forster
Karen H. Ashe
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
4Geriatric Research, Education, and Clinical Centers, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417
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Peng Liu
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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  • A clarification of mouse behavioral data
    Peng Liu
    Submitted on: 15 December 2023
  • Submitted on: (15 December 2023)
    Page navigation anchor for A clarification of mouse behavioral data
    A clarification of mouse behavioral data
    • Peng Liu, Assistant Professor of Neurology, University of Minnesota, Twin Cities, Minnesota

    The data in Figures 5B, C, and D in Steuer et al., 2022 and in Figures 5D, E, and F in Gamache et al., 2020 were acquired concurrently, but the figures reported different data and statistical analyses.

    Steuer EL, Kemper LJ, Hlynialuk CJW, Leinonen-Wright K, Montonye ML, Lapcinski IP, Forster CL, Ashe KH, Liu P (2022) Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia. J Neurosci 42:4737–4754. https://doi.org/10.1523/JNEUROSCI.0543-22.2022

    Gamache JE, Kemper L, Steuer E, Leinonen-Wright K, Choquette JM, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob MD, Ashe KH (2020) Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice. J Neurosci 40:220–236. https://doi.org/10.1523/JNEUROSCI.1256-19.2019

    Competing Interests: None declared.
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The Journal of Neuroscience: 42 (23)
Journal of Neuroscience
Vol. 42, Issue 23
8 Jun 2022
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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022

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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022
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Keywords

  • cognition
  • dementia
  • microtubule-associated protein tau
  • mouse model
  • neurodegeneration
  • synapse

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Jump to comment:

  • A clarification of mouse behavioral data
    Peng Liu
    Published on: 15 December 2023
  • Published on: (15 December 2023)
    Page navigation anchor for A clarification of mouse behavioral data
    A clarification of mouse behavioral data
    • Peng Liu, Assistant Professor of Neurology, University of Minnesota, Twin Cities, Minnesota

    The data in Figures 5B, C, and D in Steuer et al., 2022 and in Figures 5D, E, and F in Gamache et al., 2020 were acquired concurrently, but the figures reported different data and statistical analyses.

    Steuer EL, Kemper LJ, Hlynialuk CJW, Leinonen-Wright K, Montonye ML, Lapcinski IP, Forster CL, Ashe KH, Liu P (2022) Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia. J Neurosci 42:4737–4754. https://doi.org/10.1523/JNEUROSCI.0543-22.2022

    Gamache JE, Kemper L, Steuer E, Leinonen-Wright K, Choquette JM, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob MD, Ashe KH (2020) Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice. J Neurosci 40:220–236. https://doi.org/10.1523/JNEUROSCI.1256-19.2019

    Competing Interests: None declared.

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