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Cover ArticleResearch Articles, Neurobiology of Disease

Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia

Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe and Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: https://doi.org/10.1523/JNEUROSCI.0543-22.2022
Elizabeth L. Steuer
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Lisa J. Kemper
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Chris J.W. Hlynialuk
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Kailee Leinonen-Wright
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Michelle L. Montonye
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Ian P. Lapcinski
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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Colleen L. Forster
1N. Bud Grossman Center for Memory Research and Care
3UMN Academic Health Center Biological Materials Procurement Network, University of Minnesota, Minneapolis, Minnesota 55455
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  • ORCID record for Colleen L. Forster
Karen H. Ashe
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
4Geriatric Research, Education, and Clinical Centers, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417
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Peng Liu
1N. Bud Grossman Center for Memory Research and Care
2Department of Neurology
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The Journal of Neuroscience: 42 (23)
Journal of Neuroscience
Vol. 42, Issue 23
8 Jun 2022
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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022

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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Journal of Neuroscience 8 June 2022, 42 (23) 4737-4754; DOI: 10.1523/JNEUROSCI.0543-22.2022
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Keywords

  • cognition
  • dementia
  • microtubule-associated protein tau
  • mouse model
  • neurodegeneration
  • synapse

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