Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice

Guodong Huang; Daniel W. Bloodgood; Jongkyun Kang; Anu Shahapal; Phoenix Chen; Konstantin Kaganovsky; Jae-Ick Kim; Jun B. Ding; Jie Shen

doi:10.1523/JNEUROSCI.0140-22.2022

Research Articles, Neurobiology of Disease

Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice

Guodong Huang, Daniel W. Bloodgood, Jongkyun Kang, Anu Shahapal, Phoenix Chen, Konstantin Kaganovsky, Jae-Ick Kim, Jun B. Ding and Jie Shen

Journal of Neuroscience 8 June 2022, 42 (23) 4755-4765; DOI: https://doi.org/10.1523/JNEUROSCI.0140-22.2022

Guodong Huang

1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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Daniel W. Bloodgood

3Departments of Neurosurgery and

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Jongkyun Kang

1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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Anu Shahapal

1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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Phoenix Chen

1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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Konstantin Kaganovsky

3Departments of Neurosurgery and

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Jae-Ick Kim

3Departments of Neurosurgery and

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Jun B. Ding

3Departments of Neurosurgery and

4Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305

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ORCID record for Jun B. Ding

Jie Shen

1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

2Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115

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Journal of Neuroscience

Vol. 42, Issue 23

8 Jun 2022

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Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice

Guodong Huang, Daniel W. Bloodgood, Jongkyun Kang, Anu Shahapal, Phoenix Chen, Konstantin Kaganovsky, Jae-Ick Kim, Jun B. Ding, Jie Shen

Journal of Neuroscience 8 June 2022, 42 (23) 4755-4765; DOI: 10.1523/JNEUROSCI.0140-22.2022

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Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice

Guodong Huang, Daniel W. Bloodgood, Jongkyun Kang, Anu Shahapal, Phoenix Chen, Konstantin Kaganovsky, Jae-Ick Kim, Jun B. Ding, Jie Shen

Journal of Neuroscience 8 June 2022, 42 (23) 4755-4765; DOI: 10.1523/JNEUROSCI.0140-22.2022

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dopamine release
knock-out mice
LRRK2
Parkinson's disease
SNpc
striatum

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