Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons

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¹MD/PhD Program
²Center for Neuroscience and Regeneration Research and
³Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510
⁴Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516

Author contributions: G.P.H.-R., E.J.A., S.D.D.-H., and S.G.W. designed research; G.P.H.-R., M.A., S.T., N.S., and M.E. performed research; G.P.H.-R., M.A., S.T., N.S., and M.E. analyzed data; G.P.H.-R. wrote the first draft of the paper; G.P.H.-R., S.T., S.D.D.-H., and S.G.W. edited the paper; G.P.H.-R., S.D.D.-H., and S.G.W. wrote the paper; E.J.A., F.B.D.-H., S.L., D.S., and P.Z. contributed unpublished reagents/analytic tools.

This work was supported by Merit Review Award B9253-C and BX004899 from the U.S. Department of Veterans Affairs Rehabilitation Research and Development Service and Biomedical Laboratory Research and Development Service to S.G.W. and S.D.D.-H., respectively. The Center for Neuroscience & Regeneration Research is a Collaboration of the Paralyzed Veterans of America with Yale University. G.P.H.-R. was supported by National Institute of Neurological Disorders and Stroke 1F31NS122417-01. G.P.H.-R., M.A., and S.T. were supported by National Institutes of Health/National Institute of General Medical Sciences Medical Scientist Training Program T32GM007205. M.A. was supported by Yale Stem Cell Center Lo Graduate Fellowship for Excellence in Stem Cell Research. E.J.A. was supported by Paralyzed Veterans of America Research Foundation Grant 3176. We thank Shawn Ferguson, David Zenisek, Emile Boulpaep, Craig Crews, Angeliki Louvi, Fred Gorelick, and Reiko Fitzsimonds for helpful discussions; and Luke Lavis and Jonathan Grimm for the JaneliaFluors and helpful discussions.
The authors declare no competing financial interests.
Correspondence should be addressed to Sulayman D. Dib-Hajj at sulayman.dib-hajj{at}yale.edu or Stephen G. Waxman at stephen.waxman{at}yale.edu

U.S. Dept. of Veterans Affairs Rehabilitation Research and Development Service
B9253-C
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
1F31NS122417-01
HHS | NIH | National Institute of General Medical Sciences (NIGMS)
T32GM007205
Yale Stem Cell Center Lo Graduate Fellowship
Paralyzed Veterans of America Research Foundation (PVA)
#3176
U.S. Dept. of Veterans Affairs Biomedical Laboratory Research and Development Service
BX004899