Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice

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¹Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
²Emergency Department, Xiang'an Hospital of Xiamen University, Xiamen, Fujian 361102, China
³Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China

Author contributions: J.M., L.H., and Y.Z. designed research; J.M., L.H., N.Z., T.W., Hui.X., Y.J., Z.W., and Z.L. performed research; Q.Z. contributed unpublished reagents/analytic tools; J.M., L.H., N.Z., T.W., Hui.X., X.Z., H.L., D.C., J.L., Hua.Xu., and Y.-w.Z. analyzed data; J.M. and L.H. wrote the first draft of the paper; Y.-w.Z. edited the paper; Y.-w.Z. wrote the paper.
↵*J.M. and L.H. contributed equally to this work as co-first authors.

This work was supported by National Natural Science Foundation of China Grants U1705285, U21A20361, 82130039, and 81771377 (to Y.-w.Z.) and 92049202 and 92149303 (to Hua. Xu.); the National Key Research and Development Program of China Grant 2018YFC2000400 (to Y.-w.Z.); and The Major Program of Brain Science and Brain-Like Intelligence Technology Grant 2021ZD0202400 (to Hua. Xu.). We thank Dr. Nengming Xiao and Dr. Haibin Wang for providing Lyz2-Cre and Zp3-Cre mice, respectively.
The authors declare no competing financial interests.
Correspondence should be addressed to Yun-wu Zhang at yunzhang{at}xmu.edu.cn

National Natural Science Foundation of China (NSFC)
U1705285; U21A20361; 82130039; 81771377; 92049202; 92149303
National Key Research and Development Program of China
2018YFC2000400
The Major Program of Brain Science and Brain-Like Intelligence Technology
2021ZD0202400