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Research Articles, Cellular/Molecular

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice

Jian Meng, Linkun Han, Naizhen Zheng, Ting Wang, Hui Xu, Yiru Jiang, Zijie Wang, Zhaoji Liu, Qiuyang Zheng, Xian Zhang, Hong Luo, Dan Can, Jinsheng Lu, Huaxi Xu and Yun-wu Zhang
Journal of Neuroscience 22 June 2022, 42 (25) 4958-4979; DOI: https://doi.org/10.1523/JNEUROSCI.1644-21.2022
Jian Meng
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Linkun Han
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Naizhen Zheng
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Ting Wang
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Hui Xu
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Yiru Jiang
2Emergency Department, Xiang'an Hospital of Xiamen University, Xiamen, Fujian 361102, China
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Zijie Wang
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Zhaoji Liu
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
3Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China
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Qiuyang Zheng
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Xian Zhang
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Hong Luo
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Dan Can
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Jinsheng Lu
2Emergency Department, Xiang'an Hospital of Xiamen University, Xiamen, Fujian 361102, China
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Huaxi Xu
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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Yun-wu Zhang
1Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China
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The Journal of Neuroscience: 42 (25)
Journal of Neuroscience
Vol. 42, Issue 25
22 Jun 2022
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Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice
Jian Meng, Linkun Han, Naizhen Zheng, Ting Wang, Hui Xu, Yiru Jiang, Zijie Wang, Zhaoji Liu, Qiuyang Zheng, Xian Zhang, Hong Luo, Dan Can, Jinsheng Lu, Huaxi Xu, Yun-wu Zhang
Journal of Neuroscience 22 June 2022, 42 (25) 4958-4979; DOI: 10.1523/JNEUROSCI.1644-21.2022

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Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice
Jian Meng, Linkun Han, Naizhen Zheng, Ting Wang, Hui Xu, Yiru Jiang, Zijie Wang, Zhaoji Liu, Qiuyang Zheng, Xian Zhang, Hong Luo, Dan Can, Jinsheng Lu, Huaxi Xu, Yun-wu Zhang
Journal of Neuroscience 22 June 2022, 42 (25) 4958-4979; DOI: 10.1523/JNEUROSCI.1644-21.2022
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Keywords

  • autism spectrum disorders
  • CD93
  • microglia
  • neuronal transmission
  • synaptic phagocytosis
  • TMEM59

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