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Featured ArticleResearch Articles, Development/Plasticity/Repair

Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model

Niamh Moriarty, Jessica A. Kauhausen, Chiara Pavan, Cameron P.J. Hunt, Isabelle R. de Luzy, Vanessa Penna, Charlotte M. Ermine, Lachlan H. Thompson and Clare L. Parish
Journal of Neuroscience 22 June 2022, 42 (25) 4995-5006; DOI: https://doi.org/10.1523/JNEUROSCI.2431-21.2022
Niamh Moriarty
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Jessica A. Kauhausen
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Chiara Pavan
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Cameron P.J. Hunt
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Isabelle R. de Luzy
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Vanessa Penna
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Charlotte M. Ermine
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Lachlan H. Thompson
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Clare L. Parish
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2431-21.2022
PubMed 
35610045
Published By 
Society for Neuroscience
History 
  • Received December 12, 2021
  • Revision received April 14, 2022
  • Accepted April 15, 2022
  • First published May 24, 2022.
  • Version of record published June 22, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Niamh Moriarty,
  2. Jessica A. Kauhausen,
  3. Chiara Pavan,
  4. Cameron P.J. Hunt,
  5. Isabelle R. de Luzy,
  6. Vanessa Penna,
  7. Charlotte M. Ermine,
  8. Lachlan H. Thompson, and
  9. Clare L. Parish
  1. Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Author contributions

  1. Author contributions: C.L.P. and L.H.T. designed research; C.L.P., J.A.K., I.R.d.L., C.M.E., L.H.T., N.M., C.P.J.H., V.P., and C.P. performed research; C.L.P., J.A.K., I.R.d.L., C.M.E., L.H.T., N.M., C.P.J.H., V.P., and C.P. analyzed data; C.L.P. and N.M. wrote the first draft of the paper; C.L.P., J.A.K., I.R.d.L., C.M.E., L.H.T., N.M., C.P.J.H., V.P., and C.P. edited the paper.

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Disclosures

    • Received December 12, 2021.
    • Revision received April 14, 2022.
    • Accepted April 15, 2022.
  • This work was supported by the National Health and Medical Research Council (NHMRC) Australia. C.P. was supported by an NHMRC Australia Senior Research Fellowship. I.R.d.L. and V.P. were supported by University of Melbourne International Scholarships, Australia. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. We thank Ms. Brianna Xuereb and Ms. Mong Tien for their expert technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Clare L. Parish at clare.parish{at}florey.edu.au or Lachlan H. Thompson at lachlan.thompson{at}florey.edu.au

Funding

  • Department of Health | National Health and Medical Research Council (NHMRC)

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  • previous version (May 24, 2022).
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The Journal of Neuroscience: 42 (25)
Journal of Neuroscience
Vol. 42, Issue 25
22 Jun 2022
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Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model
Niamh Moriarty, Jessica A. Kauhausen, Chiara Pavan, Cameron P.J. Hunt, Isabelle R. de Luzy, Vanessa Penna, Charlotte M. Ermine, Lachlan H. Thompson, Clare L. Parish
Journal of Neuroscience 22 June 2022, 42 (25) 4995-5006; DOI: 10.1523/JNEUROSCI.2431-21.2022

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Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model
Niamh Moriarty, Jessica A. Kauhausen, Chiara Pavan, Cameron P.J. Hunt, Isabelle R. de Luzy, Vanessa Penna, Charlotte M. Ermine, Lachlan H. Thompson, Clare L. Parish
Journal of Neuroscience 22 June 2022, 42 (25) 4995-5006; DOI: 10.1523/JNEUROSCI.2431-21.2022
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Keywords

  • dopamine
  • human pluripotent stem cells
  • Parkinson's disease
  • synaptic plasticity
  • target acquisition
  • transplantation

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