Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang; Chien-Yu Lin; Yu-Mei Lin; Luc Buée; Nicolas Sergeant; David Blum; Yijuang Chern; Guey-Shin Wang

doi:10.1523/JNEUROSCI.2006-21.2022

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Research Articles, Neurobiology of Disease

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern and Guey-Shin Wang

Journal of Neuroscience 22 June 2022, 42 (25) 5102-5114; DOI: https://doi.org/10.1523/JNEUROSCI.2006-21.2022

Lee-Hsin Wang

1Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan

2Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan

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Chien-Yu Lin

2Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan

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Yu-Mei Lin

2Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan

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Luc Buée

4Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S1172, “Alzheimer & Tauopathies”, University of Lille, 59045, Lille, France

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ORCID record for Luc Buée

Nicolas Sergeant

4Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S1172, “Alzheimer & Tauopathies”, University of Lille, 59045, Lille, France

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David Blum

4Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S1172, “Alzheimer & Tauopathies”, University of Lille, 59045, Lille, France

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Yijuang Chern

1Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan

2Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan

3Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan

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Guey-Shin Wang

1Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan

2Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan

3Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan

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Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern, Guey-Shin Wang

Journal of Neuroscience 22 June 2022, 42 (25) 5102-5114; DOI: 10.1523/JNEUROSCI.2006-21.2022

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Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern, Guey-Shin Wang

Journal of Neuroscience 22 June 2022, 42 (25) 5102-5114; DOI: 10.1523/JNEUROSCI.2006-21.2022

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Keywords

Alzheimer's disease
calpain-2
excitotoxicity
MBNL2
myotonic dystrophy
RNA-processing

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