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Cover ArticleFeatured ArticleResearch Articles, Cellular/Molecular

Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model

Qian Shi, Cheng Chang, Afaf Saliba and Manzoor A. Bhat
Journal of Neuroscience 6 July 2022, 42 (27) 5294-5313; DOI: https://doi.org/10.1523/JNEUROSCI.2427-21.2022
Qian Shi
Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229
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Cheng Chang
Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229
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Afaf Saliba
Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229
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Manzoor A. Bhat
Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2427-21.2022
PubMed 
35672148
Published By 
Society for Neuroscience
History 
  • Received December 11, 2021
  • Revision received May 4, 2022
  • Accepted May 5, 2022
  • First published June 7, 2022.
  • Version of record published July 6, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Qian Shi,
  2. Cheng Chang,
  3. Afaf Saliba, and
  4. Manzoor A. Bhat
  1. Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229
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Author contributions

  1. Author contributions: Q.S. and M.B. designed research; Q.S., C.C., and A.S. performed research; Q.S., C.C., A.S., and M.A.B. analyzed data; Q.S. wrote the first draft of the paper; Q.S. and M.A.B. edited the paper.

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Disclosures

    • Received December 11, 2021.
    • Revision received May 4, 2022.
    • Accepted May 5, 2022.
  • This work was supported by the Zachry Foundation Endowment for advancing neuroscience research, the Doran Family Foundation and the University of Texas Health San Antonio (M.A.B.). We thank members of the Bhat lab for input and helpful discussions and Dr. Chu Chen for discussions and allowing us to use his lab facilities. We also thank Dr. S. Banerjee, Dr. C. Chen, and Dr. P. Sung for critical comments on this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Manzoor A. Bhat at bhatm{at}uthscsa.edu

Funding

  • Institutional Support

  • Foundation Support

Other Version

  • previous version (June 07, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (27)
Journal of Neuroscience
Vol. 42, Issue 27
6 Jul 2022
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Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
Qian Shi, Cheng Chang, Afaf Saliba, Manzoor A. Bhat
Journal of Neuroscience 6 July 2022, 42 (27) 5294-5313; DOI: 10.1523/JNEUROSCI.2427-21.2022

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Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
Qian Shi, Cheng Chang, Afaf Saliba, Manzoor A. Bhat
Journal of Neuroscience 6 July 2022, 42 (27) 5294-5313; DOI: 10.1523/JNEUROSCI.2427-21.2022
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Keywords

  • Alzheimer's disease
  • microglia
  • β-amyloid
  • mTOR
  • Trem2
  • rapamycin

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