This image shows the cortex of a mouse in which endogenous Na_v1.6 channels (green) were labeled via CRISPR/Cas9-mediated genome editing. This labeling technique allows channels to be tracked with super-resolution live-cell imaging. Blue shows DNA-DAPI stain. For more information, see the article by Liu et al. (pages 5482–5498). Cover image: Hui Liu and Zhe Liu.