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Research Articles, Behavioral/Cognitive

Selective Prefrontal–Amygdala Circuit Interactions Underlie Social and Nonsocial Valuation in Rhesus Macaques

Maia S. Pujara, Nicole K. Ciesinski, Joseph F. Reyelts, Sarah E.V. Rhodes and Elisabeth A. Murray
Journal of Neuroscience 13 July 2022, 42 (28) 5593-5604; DOI: https://doi.org/10.1523/JNEUROSCI.0794-21.2022
Maia S. Pujara
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Nicole K. Ciesinski
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Joseph F. Reyelts
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Sarah E.V. Rhodes
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Elisabeth A. Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0794-21.2022
PubMed 
35654604
Published By 
Society for Neuroscience
History 
  • Received April 11, 2021
  • Revision received April 17, 2022
  • Accepted May 17, 2022
  • First published June 2, 2022.
  • Version of record published July 13, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Maia S. Pujara,
  2. Nicole K. Ciesinski,
  3. Joseph F. Reyelts,
  4. Sarah E.V. Rhodes, and
  5. Elisabeth A. Murray
  1. Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892
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Author contributions

  1. Author contributions: M.S.P., S.E.V.R., and E.A.M. designed research; M.S.P., S.E.V.R., and E.A.M. performed research; M.S.P., N.K.C., and J.F.R. analyzed data; and M.S.P. and E.A.M. wrote the paper.

Disclosures

    • Received April 11, 2021.
    • Revision received April 17, 2022.
    • Accepted May 17, 2022.
  • This work was supported by the Intramural Research Program of the National Institute of Mental Health (Grant ZIAMH002887 to E.A.M.). M.S.P. was supported by a National Institutes of Health Center for Compulsive Behavior Postdoctoral Fellowship. We thank Dawn Lundgren, Emily Moylan, and Emily Fiuzat for assistance with data collection; Richard Saunders and Emily Moylan for help performing surgery; and Ben Jung, Jakob Seidlitz, and Adam Messinger for assistance with the lesion assessments. We also thank the staff of the Nuclear Magnetic Resonance Facility, National Institute of Neurological Disorders and Stroke, and the Laboratory of Diagnostic and Radiology Research.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Elisabeth A. Murray at murraye{at}mail.nih.gov

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    ZIAMH002887
  • HHS | NIH | Center on Compulsive Behaviors

Other Version

  • previous version (June 02, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (28)
Journal of Neuroscience
Vol. 42, Issue 28
13 Jul 2022
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Selective Prefrontal–Amygdala Circuit Interactions Underlie Social and Nonsocial Valuation in Rhesus Macaques
Maia S. Pujara, Nicole K. Ciesinski, Joseph F. Reyelts, Sarah E.V. Rhodes, Elisabeth A. Murray
Journal of Neuroscience 13 July 2022, 42 (28) 5593-5604; DOI: 10.1523/JNEUROSCI.0794-21.2022

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Selective Prefrontal–Amygdala Circuit Interactions Underlie Social and Nonsocial Valuation in Rhesus Macaques
Maia S. Pujara, Nicole K. Ciesinski, Joseph F. Reyelts, Sarah E.V. Rhodes, Elisabeth A. Murray
Journal of Neuroscience 13 July 2022, 42 (28) 5593-5604; DOI: 10.1523/JNEUROSCI.0794-21.2022
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Keywords

  • amygdala
  • decision-making
  • lesions
  • medial frontal cortex
  • orbitofrontal cortex
  • social cognition

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