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Research Articles, Cellular/Molecular

In Vivo Optogenetics Reveals Control of Cochlear Electromechanical Responses by Supporting Cells

Victoria A. Lukashkina, Snezana Levic, Patrício Simões, Zhenhang Xu, Joseph A. DiGuiseppi, Jian Zuo, Andrei N. Lukashin and Ian J. Russell
Journal of Neuroscience 20 July 2022, 42 (29) 5660-5671; DOI: https://doi.org/10.1523/JNEUROSCI.2127-21.2022
Victoria A. Lukashkina
1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
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Snezana Levic
1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
3Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, United Kingdom
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Patrício Simões
1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
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Zhenhang Xu
2Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178
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Joseph A. DiGuiseppi
2Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178
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Jian Zuo
2Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178
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Andrei N. Lukashin
1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
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Ian J. Russell
1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2127-21.2022
PubMed 
35732495
Published By 
Society for Neuroscience
History 
  • Received October 25, 2021
  • Revision received March 25, 2022
  • Accepted April 17, 2022
  • First published June 22, 2022.
  • Version of record published July 20, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Victoria A. Lukashkina1,
  2. Snezana Levic1,3,
  3. Patrício Simões1,
  4. Zhenhang Xu2,
  5. Joseph A. DiGuiseppi2,
  6. Jian Zuo2,
  7. Andrei N. Lukashin1, and
  8. Ian J. Russell1
  1. 1Sensory Neuroscience Research Group, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
  2. 2Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178
  3. 3Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, United Kingdom
  • P. Simões' present address: Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

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Author contributions

  1. Author contributions: I.J.R., J.Z., and A.N.L. designed research; I.J.R., V.A.L., S.L., P.S., Z.X., J.A.D., and A.N.L. performed research; I.J.R., V.A.L., S.L., P.S., J.Z., Z.X., J.A.D., and A.N.L. analyzed data; I.J.R. wrote the first draft of the paper; I.J.R., V.A.L., S.L., P.S., J.Z., and A.N.L. edited the paper; I.J.R. and A.N.L. wrote the paper.

  • P. Simões' present address: Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

Disclosures

    • Received October 25, 2021.
    • Revision received March 25, 2022.
    • Accepted April 17, 2022.
  • This work was supported by Medical Research Council Grant MR/N004299/1. We thank Sarath Vijayakumar and Cassidy Nguyen for technical assistance on mouse colony management at Creighton University; and Milos Stankovic for assistance with Figure 1A.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Ian J. Russell at I.Russell{at}brighton.ac.uk or Jian Zuo at JianZuo{at}creighton.edu

Funding

  • Medical Research Counclil

    MR/ N004299/1

Other Version

  • previous version (June 22, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (29)
Journal of Neuroscience
Vol. 42, Issue 29
20 Jul 2022
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In Vivo Optogenetics Reveals Control of Cochlear Electromechanical Responses by Supporting Cells
Victoria A. Lukashkina, Snezana Levic, Patrício Simões, Zhenhang Xu, Joseph A. DiGuiseppi, Jian Zuo, Andrei N. Lukashin, Ian J. Russell
Journal of Neuroscience 20 July 2022, 42 (29) 5660-5671; DOI: 10.1523/JNEUROSCI.2127-21.2022

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In Vivo Optogenetics Reveals Control of Cochlear Electromechanical Responses by Supporting Cells
Victoria A. Lukashkina, Snezana Levic, Patrício Simões, Zhenhang Xu, Joseph A. DiGuiseppi, Jian Zuo, Andrei N. Lukashin, Ian J. Russell
Journal of Neuroscience 20 July 2022, 42 (29) 5660-5671; DOI: 10.1523/JNEUROSCI.2127-21.2022
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Keywords

  • cochlea
  • cochlear amplifier
  • cochlear supporting cells
  • optogenetics
  • organ of Corti
  • outer hair cells

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