Prefrontal GABAA(δ)R Promotes Fear Extinction through Enabling the Plastic Regulation of Neuronal Intrinsic Excitability

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¹Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang 330031, People's Republic of China
²Department of Biological Science, School of Life Sciences, Nanchang University, Nanchang 330031, People's Republic of China
³Center for Medical Experiments, Nanchang University, Nanchang 330031, People's Republic of China
⁴Neurology Department, The Second Xiangya Hospital, Central South University, Changsha 410011, People's Republic of China
⁵Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China

Author contributions: H.-Q.P. and B.-X.P. designed research; H.-Q.P., X.-X.L., Y.H., J.Z., C.-Z.L., W.-J.Y., S.-Y.J., and W.-B.C. performed research; H.-Q.P., X.-X.L., Y.H., C.-Z.L., W.-J.Y., S.-Y.J., X.Q., and W.-B.C. contributed unpublished reagents/analytic tools; H.-Q.P., X.-X.L., Y.H., J.Z., C.-Z.L., W.-J.Y., and X.Q. analyzed data; H.-Q.P., E.-K.F., W.-H.Z., and B.-X.P. wrote the paper.

This work was supported by the National Key R&D Program of China (Grant 2021ZD0202704), the National Natural Science Foundation of China (Grants 82125010, 81930032, 31970953, 32160193, and 81771459), and the Natural Science Foundation of Jiangxi Province (Grants 20172BCB22005, 20192ACB20023, and 20212ACB206038).
The authors declare no competing financial interests.
Correspondence should be addressed to Bing-Xing Pan at panbingxing{at}ncu.edu.cn

MOST | National Key Research and Development Program of China (NKPs)
2021ZD0202704
National Natural Science Foundation of China (NSFC)
82125010; 81930032; 81771459; 31970953; 32160193
Natural Science Foundation of Jiangxi Province (Jiangxi Province natural Science Fund)
20172BCB22005; 20192ACB20023; 20212ACB206038

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