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Research Articles, Systems/Circuits

Neuroendocrine Stress Axis-Dependence of Duloxetine Analgesia (Anti-Hyperalgesia) in Chemotherapy-Induced Peripheral Neuropathy

Larissa Staurengo-Ferrari, Ivan J. M. Bonet, Dioneia Araldi, Paul G. Green and Jon D. Levine
Journal of Neuroscience 19 January 2022, 42 (3) 405-415; DOI: https://doi.org/10.1523/JNEUROSCI.1691-21.2021
Larissa Staurengo-Ferrari
1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
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Ivan J. M. Bonet
1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
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Dioneia Araldi
1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
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Paul G. Green
1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
2Departments of Preventative & Restorative Dental Sciences and Oral & Maxillofacial Surgery, University of California at San Francisco, San Francisco, California 94143
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Jon D. Levine
1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
3Department of Medicine, University of California at San Francisco, San Francisco, California 94143
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1691-21.2021
PubMed 
34880120
Published By 
Society for Neuroscience
History 
  • Received August 18, 2021
  • Revision received October 29, 2021
  • Accepted November 20, 2021
  • First published December 8, 2021.
  • Version of record published January 19, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Larissa Staurengo-Ferrari1,
  2. Ivan J. M. Bonet1,
  3. Dioneia Araldi1,
  4. Paul G. Green1,2, and
  5. Jon D. Levine1,3
  1. 1Department of Oral & Maxillofacial Surgery, Division of Neuroscience, UCSF Pain and Addiction Research Center, University of California at San Francisco, San Francisco, California 94143
  2. 2Departments of Preventative & Restorative Dental Sciences and Oral & Maxillofacial Surgery, University of California at San Francisco, San Francisco, California 94143
  3. 3Department of Medicine, University of California at San Francisco, San Francisco, California 94143
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Author contributions

  1. Author contributions: L.S.-F., P.G.G., and J.D.L. designed research; L.S.-F., I.J.M.B., D.A., and P.G.G. performed research; L.S.-F. and P.G.G. analyzed data; L.S.-F. wrote the first draft of the paper; P.G.G. and J.D.L. edited the paper; P.G.G. and J.D.L. wrote the paper.

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Disclosures

    • Received August 18, 2021.
    • Revision received October 29, 2021.
    • Accepted November 20, 2021.
  • This work was supported by National Institutes of Health, National Cancer Institute Grant CA250017. We thank Niloufar Mansooralavi for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jon D. Levine at Jon.Levine{at}ucsf.edu

Funding

  • NIH National Cancer Institute

    CA250017

Other Version

  • previous version (December 08, 2021).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (3)
Journal of Neuroscience
Vol. 42, Issue 3
19 Jan 2022
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Neuroendocrine Stress Axis-Dependence of Duloxetine Analgesia (Anti-Hyperalgesia) in Chemotherapy-Induced Peripheral Neuropathy
Larissa Staurengo-Ferrari, Ivan J. M. Bonet, Dioneia Araldi, Paul G. Green, Jon D. Levine
Journal of Neuroscience 19 January 2022, 42 (3) 405-415; DOI: 10.1523/JNEUROSCI.1691-21.2021

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Neuroendocrine Stress Axis-Dependence of Duloxetine Analgesia (Anti-Hyperalgesia) in Chemotherapy-Induced Peripheral Neuropathy
Larissa Staurengo-Ferrari, Ivan J. M. Bonet, Dioneia Araldi, Paul G. Green, Jon D. Levine
Journal of Neuroscience 19 January 2022, 42 (3) 405-415; DOI: 10.1523/JNEUROSCI.1691-21.2021
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Keywords

  • CIPN
  • oxaliplatin
  • paclitaxel
  • pain
  • sex differences
  • stress

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