Research Articles, Neurobiology of Disease

Theta-Burst Stimulation of Primary Afferents Drives Long-Term Potentiation in the Spinal Cord and Persistent Pain via α2δ-1-Bound NMDA Receptors

Yuying Huang (黄玉莹), Shao-Rui Chen (陈少瑞), Hong Chen (陈红), Jing-Jing Zhou (周京京), Daozhong Jin (金道忠) and Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 19 January 2022, 42 (3) 513-527; https://doi.org/10.1523/JNEUROSCI.1968-21.2021

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  • Submitted on: (22 March 2022)
    Page navigation anchor for RE: Reply to comments on LTP induced by tetanic stimulation by Li
    RE: Reply to comments on LTP induced by tetanic stimulation by Li
    • Yuying Huang, Neuroscientist, MD Anderson Cancer Center
    • Other Contributors:
      • Shao-Rui Chen
      • Hui-Lin Pan

    Thank you for your interest and feedback on our study. For data shown in Fig. 1A and 1B, we used a 2x3 contingency table for the Chi-square test to compare the effect of 2 stimulation methods on 3 different types of neuronal responses. Because LTD, like LTP, is a distinct synaptic plasticity, we compared the difference in the occurrence of both LTP and LTD between the 2 induction protocols. We did not simply combine the cells with LTD and those with no change as one group, as you did. Our analysis suggest that TBS induces more LTP, whereas tetanic stimulation induces more LTD, in spinal lamina II neurons. We hope that this clarifies the misunderstanding.

    Competing Interests: None declared.
  • Submitted on: (17 March 2022)
    Page navigation anchor for RE: LTP induced by tetanic stimulation in Huang et al.
    RE: LTP induced by tetanic stimulation in Huang et al.
    • Lan Li, Neuroscience student, N/A

    This is an excellent paper, but we have some minor comments about it.
    In Fig. 1A and 1B, the authors, using a chi-square test, compared proportions in three categories (LTD, LTP and no change). They concluded that “These results suggest that compared with tetanic stimulation, TBS of primary afferents induces LTP in more spinal dorsal horn neurons.” (page 517, the end of the 3rd paragraph).
    However, their results, with the chi-square test, show no statistical difference for LTP category (theta LTP: 18(+), 22(-); tetanic LTP: 14(+), 24(-); P = 0.4640). We think that the authors wrongly draw their conclusion by simply using a 2X3 Chi-square test.
    Classical tetanic stimulation induces LTP in the dorsal horn [Randić et al. 1993]; from the data shown in the current paper [Huang et al., 2022], the theta stimulation yields a similar result.

    Reference
    Randić M, Jiang MC, Cerne R. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord. J Neurosci. 1993 Dec;13(12):5228-41.

    Competing Interests: None declared.
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Theta-Burst Stimulation of Primary Afferents Drives Long-Term Potentiation in the Spinal Cord and Persistent Pain via α2δ-1-Bound NMDA Receptors
Yuying Huang (黄玉莹), Shao-Rui Chen (陈少瑞), Hong Chen (陈红), Jing-Jing Zhou (周京京), Daozhong Jin (金道忠), Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 19 January 2022, 42 (3) 513-527; DOI: 10.1523/JNEUROSCI.1968-21.2021
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  • Published on: (22 March 2022)
    Page navigation anchor for RE: Reply to comments on LTP induced by tetanic stimulation by Li
    RE: Reply to comments on LTP induced by tetanic stimulation by Li
    • Yuying Huang, Neuroscientist, MD Anderson Cancer Center
    • Other Contributors:
      • Shao-Rui Chen
      • Hui-Lin Pan

    Thank you for your interest and feedback on our study. For data shown in Fig. 1A and 1B, we used a 2x3 contingency table for the Chi-square test to compare the effect of 2 stimulation methods on 3 different types of neuronal responses. Because LTD, like LTP, is a distinct synaptic plasticity, we compared the difference in the occurrence of both LTP and LTD between the 2 induction protocols. We did not simply combine the cells with LTD and those with no change as one group, as you did. Our analysis suggest that TBS induces more LTP, whereas tetanic stimulation induces more LTD, in spinal lamina II neurons. We hope that this clarifies the misunderstanding.

    Competing Interests: None declared.
  • Published on: (17 March 2022)
    Page navigation anchor for RE: LTP induced by tetanic stimulation in Huang et al.
    RE: LTP induced by tetanic stimulation in Huang et al.
    • Lan Li, Neuroscience student, N/A

    This is an excellent paper, but we have some minor comments about it.
    In Fig. 1A and 1B, the authors, using a chi-square test, compared proportions in three categories (LTD, LTP and no change). They concluded that “These results suggest that compared with tetanic stimulation, TBS of primary afferents induces LTP in more spinal dorsal horn neurons.” (page 517, the end of the 3rd paragraph).
    However, their results, with the chi-square test, show no statistical difference for LTP category (theta LTP: 18(+), 22(-); tetanic LTP: 14(+), 24(-); P = 0.4640). We think that the authors wrongly draw their conclusion by simply using a 2X3 Chi-square test.
    Classical tetanic stimulation induces LTP in the dorsal horn [Randić et al. 1993]; from the data shown in the current paper [Huang et al., 2022], the theta stimulation yields a similar result.

    Reference
    Randić M, Jiang MC, Cerne R. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord. J Neurosci. 1993 Dec;13(12):5228-41.

    Competing Interests: None declared.