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About the Cover

July 27, 2022; Volume 42,Issue 30

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This photomicrograph reflects the experimental power of CRISPR/Cas9 genome editing. Tbx21-Cre mice were bred to a Cas9 line with a GFP reporter and then gRNA targeting the voltage dependent potassium channel, Kv1.3, was retroorbitally delivered. The CRISPR-associated Cas9 protein is restricted to the mitral and tufted output neurons of the olfactory bulb (green) allowing the CRISPR guide RNA (red) to edit the channel from the genome in the target neurons (yellow). This confers the mouse with enhanced olfaction and resistance to diet-induced obesity. For more information, see the article by Kolling et al. (pages 5966–5990). Cover image: Louis Kolling.

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The Journal of Neuroscience: 42 (30)
Journal of Neuroscience
Vol. 42, Issue 30
27 Jul 2022
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  • An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
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  • Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
  • A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
  • Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
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