DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons

Iván Fernandez Bessone; Jordi Navarro; Emanuel Martinez; Karina Karmirian; Mariana Holubiec; Matias Alloatti; Livia Goto-Silva; Cayetana Arnaiz Yepez; Daniel Martins-de-Souza; Juliana Minardi Nascimento; Luciana Bruno; Trinidad M. Saez; Stevens K. Rehen; Tomás L. Falzone

doi:10.1523/JNEUROSCI.2551-21.2022

Research Articles, Cellular/Molecular

DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons

Iván Fernandez Bessone, Jordi Navarro, Emanuel Martinez, Karina Karmirian, Mariana Holubiec, Matias Alloatti, Livia Goto-Silva, Cayetana Arnaiz Yepez, Daniel Martins-de-Souza, Juliana Minardi Nascimento, Luciana Bruno, Trinidad M. Saez, Stevens K. Rehen and Tomás L. Falzone

Journal of Neuroscience 17 August 2022, 42 (33) 6344-6358; DOI: https://doi.org/10.1523/JNEUROSCI.2551-21.2022

Iván Fernandez Bessone

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Jordi Navarro

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Emanuel Martinez

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Karina Karmirian

2D'Or Institute for Research and Education, Rio de Janeiro, Brasil, RJ, 22281-100

3Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brasil, RJ, 21941-902

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Mariana Holubiec

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Matias Alloatti

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Livia Goto-Silva

2D'Or Institute for Research and Education, Rio de Janeiro, Brasil, RJ, 22281-100

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Cayetana Arnaiz Yepez

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Daniel Martins-de-Souza

2D'Or Institute for Research and Education, Rio de Janeiro, Brasil, RJ, 22281-100

4Laboratory of Neuroproteomics, University of Campinas Campinas, Brasil, SP, 13083-970

5Instituto Nacional de Biomarcadores Em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, Brasil, SP, 13083-970

6Experimental Medicine Research Cluster, University of Campinas, Campinas, Brasil, SP, 13083-970

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Juliana Minardi Nascimento

4Laboratory of Neuroproteomics, University of Campinas Campinas, Brasil, SP, 13083-970

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Luciana Bruno

7Instituto de Cálculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina C1428EGA

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Trinidad M. Saez

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

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Stevens K. Rehen

2D'Or Institute for Research and Education, Rio de Janeiro, Brasil, RJ, 22281-100

3Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brasil, RJ, 21941-902

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Tomás L. Falzone

1Instituto de Biología Celular y Neurociencia IBCN, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina C1121ABG

8Instituto de Investigación en Biomedicina de Buenos Aires, Partner Institute of the Max Planck Society, Buenos Aires, Argentina C1425FQD

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DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons

Journal of Neuroscience 17 August 2022, 42 (33) 6344-6358; DOI: 10.1523/JNEUROSCI.2551-21.2022

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DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons

Journal of Neuroscience 17 August 2022, 42 (33) 6344-6358; DOI: 10.1523/JNEUROSCI.2551-21.2022

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Keywords

Alzheimer's disease
APP
axonal transport
DYRK1A
human neurons
motor proteins

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