Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Paige Mumford; Justin Tosh; Silvia Anderle; Eleni Gkanatsiou Wikberg; Gloria Lau; Sue Noy; Karen Cleverley; Takashi Saito; Takaomi C. Saido; Eugene Yu; Gunnar Brinkmalm; Erik Portelius; Kaj Blennow; Henrik Zetterberg; Victor Tybulewicz; Elizabeth M.C. Fisher; Frances K. Wiseman

doi:10.1523/JNEUROSCI.0521-22.2022

Featured ArticleResearch Articles, Neurobiology of Disease

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M.C. Fisher and Frances K. Wiseman

Journal of Neuroscience 17 August 2022, 42 (33) 6453-6468; DOI: https://doi.org/10.1523/JNEUROSCI.0521-22.2022

Paige Mumford

1The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Paige Mumford

Justin Tosh

2Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Silvia Anderle

1The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eleni Gkanatsiou Wikberg

3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gloria Lau

1The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sue Noy

2Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Karen Cleverley

2Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Takashi Saito

4Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama Japan, 351-0198

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Takashi Saito

Takaomi C. Saido

4Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama Japan, 351-0198

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Takaomi C. Saido

Eugene Yu

5Genetics and Genomics Program and Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Children's Guild Foundation Down Syndrome Research Program, Buffalo, New York NY 14263,

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gunnar Brinkmalm

3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Erik Portelius

3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kaj Blennow

3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden

6Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-43180, Sweden

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Henrik Zetterberg

1The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom

3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden

6Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-43180, Sweden

7Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom

8Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Victor Tybulewicz

9The Francis Crick Institute, London, NW1 1AT, United Kingdom

10Department of Immunology and Inflammation, Imperial College, London, W12 0NN, United Kingdom

11LonDownS: London Down Syndrome Consortium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Victor Tybulewicz

Elizabeth M.C. Fisher

2Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom

11LonDownS: London Down Syndrome Consortium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Frances K. Wiseman

1The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom

11LonDownS: London Down Syndrome Consortium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
Info & Metrics
eLetters
PDF

Member Log In

Log in using your username and password

Username *

Enter your Journal of Neuroscience username.

Password *

Enter the password that accompanies your username.

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

In this issue

Journal of Neuroscience

Vol. 42, Issue 33

17 Aug 2022

Table of Contents
Table of Contents (PDF)
About the Cover
Index by author
Masthead (PDF)

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Message Subject (Your Name) has forwarded a page to you from Journal of Neuroscience

Message Body (Your Name) thought you would be interested in this article in Journal of Neuroscience.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

View Full Page PDF

Citation Tools

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Journal of Neuroscience 17 August 2022, 42 (33) 6453-6468; DOI: 10.1523/JNEUROSCI.0521-22.2022

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Respond to this article

Request Permissions

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Journal of Neuroscience 17 August 2022, 42 (33) 6453-6468; DOI: 10.1523/JNEUROSCI.0521-22.2022

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Jump to section

Article
Figures & Data
Info & Metrics
eLetters
PDF

Keywords

amyloid precursor protein
amyloid-β
BACE2
Down syndrome
DYRK1A

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Cited By...

Research Articles

Carbogen-induced respiratory acidosis blocks experimental seizures by a direct and specific inhibition of Na_V1.2 channels in the axon initial segment of pyramidal neurons
Modulation of motor vigour by expectation of reward probability trial-by-trial is preserved in healthy ageing and Parkinson's disease patients
The neural basis for biased behavioral responses evoked by galvanic vestibular stimulation in primates

Show more Research Articles

Neurobiology of Disease

TEMPORAL IRREVERSIBILITY OF LARGE-SCALE BRAIN DYNAMICS IN ALZHEIMER'S DISEASE
Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation
Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats

Show more Neurobiology of Disease

Main menu

User menu

Search

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Member Log In

Purchase access

In this issue

Citation Manager Formats

Keywords

Responses to this article

Jump to comment:

Related Articles

Cited By...

More in this TOC Section

Research Articles

Neurobiology of Disease