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Research Articles, Behavioral/Cognitive

Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms

Büşra Tanriverdi, David F. Gregory, Thomas M. Olino, Timothy D. Ely, Nathaniel G. Harnett, Sanne J.H. van Rooij, Lauren A.M. Lebois, Antonia V. Seligowski, Tanja Jovanovic, Kerry J. Ressler, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Steven E. Harte, James M. Elliott, Samuel A. McLean, Ronald C. Kessler, Karestan C. Koenen, Jennifer S. Stevens and Vishnu P. Murty
Journal of Neuroscience 24 August 2022, 42 (34) 6593-6604; DOI: https://doi.org/10.1523/JNEUROSCI.0911-21.2022
Büşra Tanriverdi
1Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania 19121
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David F. Gregory
1Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania 19121
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Thomas M. Olino
1Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania 19121
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Timothy D. Ely
2Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329
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Nathaniel G. Harnett
3Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts 02478
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
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Sanne J.H. van Rooij
2Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329
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Lauren A.M. Lebois
3Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts 02478
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
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Antonia V. Seligowski
3Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts 02478
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
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Tanja Jovanovic
5Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48202
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Kerry J. Ressler
3Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts 02478
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
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Stacey L. House
6Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
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Francesca L. Beaudoin
7Department of Emergency Medicine & Department of Health Services, Policy, and Practice, Alpert Medical School of Brown University, Rhode Island Hospital, and Miriam Hospital, Providence, Rhode Island 02930
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Xinming An
8Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559
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Thomas C. Neylan
9Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, California 94143
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Gari D. Clifford
10Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia 30332
11Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332
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Sarah D. Linnstaedt
8Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559
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Laura T. Germine
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
12Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts 02478
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Kenneth A. Bollen
13Department of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559
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Scott L. Rauch
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
14Institute for Technology in Psychiatry/Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478
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John P. Haran
15Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Alan B. Storrow
16Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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Christopher Lewandowski
17Department of Emergency Medicine, Henry Ford Health System, Detroit, Michigan 48202
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Paul I. Musey
18Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202
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Phyllis L. Hendry
19Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida 32209
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Sophia Sheikh
19Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida 32209
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Christopher W. Jones
20Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey 08103
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Brittany E. Punches
21Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
22College of Nursing, University of Cincinnati, Cincinnati, Ohio 45221
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Michael C. Kurz
23Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama 35294
24Department of Surgery, Division of Acute Care Surgery, University of Alabama School of Medicine, Birmingham, Alabama 35294
25Center for Injury Science, University of Alabama at Birmingham, Birmingham, Alabama 35294
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Meghan E. McGrath
26Department of Emergency Medicine, Boston Medical Center, Boston, Massachusetts 02118
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Lauren A. Hudak
27Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30329
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Jose L. Pascual
28Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104
29Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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Mark J. Seamon
29Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
30Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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Elizabeth M. Datner
31Department of Emergency Medicine, Einstein Healthcare Network, Philadelphia, Pennsylvania 19141
32Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Claire Pearson
33Department of Emergency Medicine, Wayne State University, Detroit, Michigan 48202
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Robert M. Domeier
34Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, Michigan 48197
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Niels K. Rathlev
35Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts 01107
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Brian J. O'Neil
33Department of Emergency Medicine, Wayne State University, Detroit, Michigan 48202
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Leon D. Sanchez
36Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215
37Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts 02115
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Steven E. Bruce
38Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, Missouri 63121
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Mark W. Miller
39National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts 02130
40Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118
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Robert H. Pietrzak
41National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut 06516
42Department of Psychiatry, Yale School of Medicine, West Haven, Connecticut 06510
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Jutta Joormann
43Department of Psychology, Yale University, West Haven, Connecticut 06520
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Deanna M. Barch
44Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri 63130
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Diego A. Pizzagalli
3Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts 02478
4Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
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John F. Sheridan
45Department of Biosciences, Ohio State University Wexner Medical Center, Columbus, Ohio 43210
46Institute for Behavioral Medicine Research, Ohio State University Wexner Medical Center, Columbus, Ohio 43211
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Jordan W. Smoller
47Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114
48Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Massachusetts 02142
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Steven E. Harte
49Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109
50Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, Michigan 48109
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James M. Elliott
51Kolling Institute of Medical Research, University of Sydney, St Leonards, New South Wales 2065, Australia
52Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2006, Australia
53Physical Therapy & Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60208
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Samuel A. McLean
8Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559
54Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559
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Ronald C. Kessler
55Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115
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Karestan C. Koenen
56Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts 02115
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Jennifer S. Stevens
2Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329
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Vishnu P. Murty
1Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania 19121
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The Journal of Neuroscience: 42 (34)
Journal of Neuroscience
Vol. 42, Issue 34
24 Aug 2022
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Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms
Büşra Tanriverdi, David F. Gregory, Thomas M. Olino, Timothy D. Ely, Nathaniel G. Harnett, Sanne J.H. van Rooij, Lauren A.M. Lebois, Antonia V. Seligowski, Tanja Jovanovic, Kerry J. Ressler, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Steven E. Harte, James M. Elliott, Samuel A. McLean, Ronald C. Kessler, Karestan C. Koenen, Jennifer S. Stevens, Vishnu P. Murty
Journal of Neuroscience 24 August 2022, 42 (34) 6593-6604; DOI: 10.1523/JNEUROSCI.0911-21.2022

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Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms
Büşra Tanriverdi, David F. Gregory, Thomas M. Olino, Timothy D. Ely, Nathaniel G. Harnett, Sanne J.H. van Rooij, Lauren A.M. Lebois, Antonia V. Seligowski, Tanja Jovanovic, Kerry J. Ressler, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Steven E. Harte, James M. Elliott, Samuel A. McLean, Ronald C. Kessler, Karestan C. Koenen, Jennifer S. Stevens, Vishnu P. Murty
Journal of Neuroscience 24 August 2022, 42 (34) 6593-6604; DOI: 10.1523/JNEUROSCI.0911-21.2022
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Keywords

  • arousal
  • fear
  • fMRI
  • hippocampus
  • trauma

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