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Research Articles, Systems/Circuits

Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale

Mehak M. Khan, Shuting Wu, Christopher H. Chen and Wade G. Regehr
Journal of Neuroscience 5 October 2022, 42 (40) 7581-7593; DOI: https://doi.org/10.1523/JNEUROSCI.1869-21.2022
Mehak M. Khan
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
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Shuting Wu
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
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Christopher H. Chen
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
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Wade G. Regehr
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1869-21.2022
PubMed 
35995561
Published By 
Society for Neuroscience
History 
  • Received September 14, 2021
  • Revision received June 30, 2022
  • Accepted August 12, 2022
  • First published August 22, 2022.
  • Version of record published October 5, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Mehak M. Khan,
  2. Shuting Wu,
  3. Christopher H. Chen, and
  4. Wade G. Regehr
  1. Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
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Author contributions

  1. Author contributions: M.M.K., S.W., C.H.C., and W.G.R. designed research; M.M.K., S.W., and C.H.C. performed research; M.M.K., S.W., C.H.C., and W.G.R. analyzed data; M.M.K., C.H.C., and W.G.R. wrote the paper.

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Disclosures

    • Received September 14, 2021.
    • Revision received June 30, 2022.
    • Accepted August 12, 2022.
  • This work was supported by National Institutes of Health Grants R01-NS-032405 and R35-NS-097284 (to W.G.R.) and K99-NS-110978 (to C.H.C.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Wade G. Regehr at wade_regehr{at}hms.harvard.edu

Funding

  • NIH

    R01NS032405; K99NS110978; R35NS097284

Other Version

  • previous version (August 22, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (40)
Journal of Neuroscience
Vol. 42, Issue 40
5 Oct 2022
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Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale
Mehak M. Khan, Shuting Wu, Christopher H. Chen, Wade G. Regehr
Journal of Neuroscience 5 October 2022, 42 (40) 7581-7593; DOI: 10.1523/JNEUROSCI.1869-21.2022

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Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale
Mehak M. Khan, Shuting Wu, Christopher H. Chen, Wade G. Regehr
Journal of Neuroscience 5 October 2022, 42 (40) 7581-7593; DOI: 10.1523/JNEUROSCI.1869-21.2022
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Keywords

  • adaptation
  • cerebellar nuclei
  • cerebellum

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