Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism

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¹Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425
²Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425
³Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
⁴Department of Otolaryngology & Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425
⁵Hollings Cancer Institute, Medical University of South Carolina, Charleston, South Carolina 29425

Author contributions: H.L. and C.W.C. designed the research; N.M., J.L.B., A.J.H., J.T., K.V.N., C.M.M., J.A.R., S.G.V., M.J.R., A.J.H., K.C.H. and H.L. performed the research; J.A.R., J.L.B., N.M., P.E., K.C.H. and H.L. analyzed data; J.L.B., and H.L. drafted the paper, C.W.C., K.C.H., J.L.B., and H.L. revised the paper, and all authors approved the paper.
↵*N.M., J.L.B. and J.A.R. contributed equally to this work.

This work was supported by National Institutes of Health Grants K18DC018517 to H.L., R01DC012058 to H.L., P50DC000422 to H.L. and K.C.H., Simons Foundation Autism Research Initiative Pilot Award 649452 to H.L. and C.W.C., R01 MH111464 to C.W.C., T32014435 to C.M.M., P30GM103342 to J.L.B., and P20GM103499 to J.L.B. Confocal image collection and analysis were done through Medical University of South Carolina (MUSC) Image facilities that were supported in part by the Cell & Molecular Imaging Shared Resource, MUSC Cancer Center Support P30 CA138313, the SC COBRE Grants P20 GM103542 and P20 GM130457, the MUSC Core Center P30 DK123704, and Shared Instrumentation Grants S10 OD018113 and S10 OD028663. Bioinformatic analysis of RNA-seq data was done through the MUSC Proteogenomics Facility that is supported by NIGMS GM103499 and the MUSC Office of the Vice President for Research. We thank John Lemasters for suggestions with the use of the mitochondrial functional markers; Nancy Smythe, Catherine Bridges, Cindy Wang, Gang Li, Shelby Storm, Juhong Zhu, Carlene Brandon, Jiaying Wu, and Logan Martin for excellent technical assistance; Richard Schmiedt for help with the system setup of single-trial ABR recording; and Jayne Ahlstrom, Nathaniel Parsons, and Cindy Wang for comments and editing of the manuscript.
The authors declare no competing financial interests.
Correspondence should be addressed to Hainan Lang at langh{at}musc.edu