Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS

Nicholas E. Karagas; Richa Gupta; Elham Rastegari; Kai Li Tan; Ho Hang Leung; Hugo J. Bellen; Kartik Venkatachalam; Ching-On Wong

doi:10.1523/JNEUROSCI.2456-21.2022

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Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS

Nicholas E. Karagas, Richa Gupta, Elham Rastegari, Kai Li Tan, Ho Hang Leung, Hugo J. Bellen, Kartik Venkatachalam and Ching-On Wong

Journal of Neuroscience 19 October 2022, 42 (42) 8019-8037; DOI: https://doi.org/10.1523/JNEUROSCI.2456-21.2022

Nicholas E. Karagas

1Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, Texas 77030

5Graduate Program in Biochemistry and Cell Biology, MD Anderson Cancer Center and University of Texas Health Sciences Center Graduate School of Biomedical Sciences, Houston, TX, 77030

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Richa Gupta

1Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, Texas 77030

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Elham Rastegari

1Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, Texas 77030

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Kai Li Tan

2Departments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, Houston, TX 77030

3Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030

4Duncan Neurological Research Institute, Texas Children Hospital, Houston, Texas 77030

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Ho Hang Leung

7Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102

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Hugo J. Bellen

2Departments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, Houston, TX 77030

3Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030

4Duncan Neurological Research Institute, Texas Children Hospital, Houston, Texas 77030

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Kartik Venkatachalam

1Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, Texas 77030

5Graduate Program in Biochemistry and Cell Biology, MD Anderson Cancer Center and University of Texas Health Sciences Center Graduate School of Biomedical Sciences, Houston, TX, 77030

6Graduate Program in Neuroscience, MD Anderson Cancer Center and University of Texas Health Sciences Center Graduate School of Biomedical Sciences, Houston, TX, 77030

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Ching-On Wong

7Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102

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19 Oct 2022

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Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS

Nicholas E. Karagas, Richa Gupta, Elham Rastegari, Kai Li Tan, Ho Hang Leung, Hugo J. Bellen, Kartik Venkatachalam, Ching-On Wong

Journal of Neuroscience 19 October 2022, 42 (42) 8019-8037; DOI: 10.1523/JNEUROSCI.2456-21.2022

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Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS

Nicholas E. Karagas, Richa Gupta, Elham Rastegari, Kai Li Tan, Ho Hang Leung, Hugo J. Bellen, Kartik Venkatachalam, Ching-On Wong

Journal of Neuroscience 19 October 2022, 42 (42) 8019-8037; DOI: 10.1523/JNEUROSCI.2456-21.2022

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ALS
Drosophila neurobiology
ER calcium channels
mitochondrial ATP production
neurodegeneration
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