Figure 5. Pseudo-unipolar sensory neurons have normal regeneration. A, Avil-Cre;Ank3f/f mice lack AnkG (red) at dorsal root nodes of Ranvier. Paranodes and nodes labeled for neurofascin (green). Scale bar, 2 µm. B, Sensory nerve endings in the intraepidermal nerve fiber layer (labeled by PGP9.5, red, arrowheads) in control and Avil-Cre;Ank3f/f mice. Scale bar, 10 µm. C, Regenerating sensory nerve endings in the intraepidermal nerve fiber layer (labeled by PGP9.5, red, arrowheads) in control and Avil-Cre;Ank3f/f mice at 14, 21, and 28 DPC. Scale bar, 10 µm. D, Quantification of sensory nerve endings in uninjured control and Avil-Cre;Ank3f/f mice in the intraepidermal nerve fiber layer per 100 µm. N = 7 or 8 mice per group and condition. Error bars indicate ±SEM. E, Quantification of sensory nerve endings in injured control and Avil-Cre;Ank3f/f mice in the intraepidermal nerve fiber layer per 100 µm at 14, 21, and 28 DPC. N = 2 or 3 mice per group and condition. Error bars indicate ±SEM or range if N = 2.