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Research Articles, Development/Plasticity/Repair

Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination

Jiajia Wang, Lijun Yang, Minqing Jiang, Chuntao Zhao, Xuezhao Liu, Kalen Berry, Ari Waisman, Abraham J. Langseth, Bennett G. Novitch, Dwight E. Bergles, Akiko Nishiyama and Q. Richard Lu
Journal of Neuroscience 9 November 2022, 42 (45) 8542-8555; https://doi.org/10.1523/JNEUROSCI.0237-22.2022
Jiajia Wang
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Lijun Yang
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Minqing Jiang
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Chuntao Zhao
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Xuezhao Liu
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Kalen Berry
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Ari Waisman
2Institute for Molecular Medicine, Langenbeckstrasse 1, Mainz, 55131, Germany
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Abraham J. Langseth
3The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
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Bennett G. Novitch
4Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095
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Dwight E. Bergles
3The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
5Johns Hopkins Kavli Neuroscience Discovery Institute, Baltimore, Maryland 21205
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  • ORCID record for Dwight E. Bergles
Akiko Nishiyama
6Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, 06269
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Q. Richard Lu
1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0237-22.2022
PubMed 
36198499
Published By 
Society for Neuroscience
History 
  • Received January 31, 2022
  • Revision received August 25, 2022
  • Accepted September 7, 2022
  • First published October 5, 2022.
  • Version of record published November 9, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Jiajia Wang1,*,
  2. Lijun Yang1,*,
  3. Minqing Jiang1,
  4. Chuntao Zhao1,
  5. Xuezhao Liu1,
  6. Kalen Berry1,
  7. Ari Waisman2,
  8. Abraham J. Langseth3,
  9. Bennett G. Novitch4,
  10. Dwight E. Bergles3,5,
  11. Akiko Nishiyama6, and
  12. Q. Richard Lu1
  1. 1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229
  2. 2Institute for Molecular Medicine, Langenbeckstrasse 1, Mainz, 55131, Germany
  3. 3The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  4. 4Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095
  5. 5Johns Hopkins Kavli Neuroscience Discovery Institute, Baltimore, Maryland 21205
  6. 6Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, 06269
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Author contributions

  1. Author contributions: J.W., L.Y., and M.J. performed research; J.W., C.Z., X.L., K.B., A.N., and Q.R.L. analyzed data; J.W., D.E.B., A.N., and Q.R.L. edited the paper; J.W. and Q.R.L. wrote the paper; L.Y., M.J., and Q.R.L. designed research; A.W., A.J.L., B.G.N., and D.E.B. contributed unpublished reagents/analytic tools.

  2. ↵*J.W. and L.Y. contributed equally to this work.

Disclosures

    • Received January 31, 2022.
    • Revision received August 25, 2022.
    • Accepted September 7, 2022.
  • This work was supported by National MS Society and Dr. Miriam and Sheldon G. Adelson Medical Research Foundation grants to D.E.B.; and National MS Society award to Q.R.L. We thank Sean Ogurek and Arman E. Bayet for technical support; and Dr. Klaus Nave for the CNP-Cre line.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Q. Richard Lu at richard.lu{at}cchmc.org

Funding

  • The national MS society

Other Version

  • previous version (October 05, 2022).
  • You are viewing the most recent version of this article.

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Oct 202213500113
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The Journal of Neuroscience: 42 (45)
Journal of Neuroscience
Vol. 42, Issue 45
9 Nov 2022
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Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination
Jiajia Wang, Lijun Yang, Minqing Jiang, Chuntao Zhao, Xuezhao Liu, Kalen Berry, Ari Waisman, Abraham J. Langseth, Bennett G. Novitch, Dwight E. Bergles, Akiko Nishiyama, Q. Richard Lu
Journal of Neuroscience 9 November 2022, 42 (45) 8542-8555; DOI: 10.1523/JNEUROSCI.0237-22.2022

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Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination
Jiajia Wang, Lijun Yang, Minqing Jiang, Chuntao Zhao, Xuezhao Liu, Kalen Berry, Ari Waisman, Abraham J. Langseth, Bennett G. Novitch, Dwight E. Bergles, Akiko Nishiyama, Q. Richard Lu
Journal of Neuroscience 9 November 2022, 42 (45) 8542-8555; DOI: 10.1523/JNEUROSCI.0237-22.2022
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Keywords

  • demyelination
  • myelination
  • Olig2
  • oligodendrocyte lineage
  • remyelination
  • white matter injury

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