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Research Articles, Development/Plasticity/Repair

Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate

Naixin Ren, Ganchao Wei, Abed Ghanbari and Ian H. Stevenson
Journal of Neuroscience 16 November 2022, 42 (46) 8608-8620; DOI: https://doi.org/10.1523/JNEUROSCI.0808-22.2022
Naixin Ren
1Departments of Psychological Sciences
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Ganchao Wei
2Statistics, University of Connecticut, Storrs, Connecticut 06269
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Abed Ghanbari
3The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032
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Ian H. Stevenson
1Departments of Psychological Sciences
4Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269
5Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, Connecticut 06269
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0808-22.2022
PubMed 
36171085
Published By 
Society for Neuroscience
History 
  • Received April 26, 2022
  • Revision received August 10, 2022
  • Accepted September 14, 2022
  • First published September 28, 2022.
  • Version of record published November 16, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Naixin Ren1,
  2. Ganchao Wei2,
  3. Abed Ghanbari3, and
  4. Ian H. Stevenson1,4,5
  1. 1Departments of Psychological Sciences
  2. 2Statistics, University of Connecticut, Storrs, Connecticut 06269
  3. 3The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032
  4. 4Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269
  5. 5Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, Connecticut 06269
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Author contributions

  1. Author contributions: N.R. and I.H.S. designed research; N.R. performed research; N.R., G.W., A.G., and I.H.S. contributed unpublished reagents/analytic tools; N.R. analyzed data; N.R., G.W., A.G., and I.H.S. wrote the paper.

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Disclosures

    • Received April 26, 2022.
    • Revision received August 10, 2022.
    • Accepted September 14, 2022.
  • This work was supported by National Science Foundation Grant 1651396. We thank Harvey Swadlow and Monty Escabi for discussions, and the staff at Allen Institute for Brain Science for sharing the Visual Coding–Neuropixels dataset and for supporting open science.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Naixin Ren at naixin.ren{at}uconn.edu

Funding

  • National Science Foundation (NSF)

    1651396

Other Version

  • previous version (September 28, 2022).
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The Journal of Neuroscience: 42 (46)
Journal of Neuroscience
Vol. 42, Issue 46
16 Nov 2022
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Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate
Naixin Ren, Ganchao Wei, Abed Ghanbari, Ian H. Stevenson
Journal of Neuroscience 16 November 2022, 42 (46) 8608-8620; DOI: 10.1523/JNEUROSCI.0808-22.2022

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Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate
Naixin Ren, Ganchao Wei, Abed Ghanbari, Ian H. Stevenson
Journal of Neuroscience 16 November 2022, 42 (46) 8608-8620; DOI: 10.1523/JNEUROSCI.0808-22.2022
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Keywords

  • in vivo
  • short-term plasticity
  • spike recordings
  • synaptic efficacy

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