Shisa7-Dependent Regulation of GABAA Receptor Single-Channel Gating Kinetics

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¹Synapse and Neural Circuit Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
²Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

Author contributions: D.C. and W.L. designed research; D.C., K.W., and A.K. performed research; D.C., K.W., and A.K. analyzed data; D.C. and W.L. wrote the paper.

This work was supported by the National Institutes of Health/National Institute of Neurological Disorders and Stroke Intramural Research Program (to W.L.). We thank Dr. Joseph Lynch for providing us with the human β3 GABA_AR subunit. We also thank Drs. Gabriela Popescu and Gary Iacobucci for providing the QuB software. In addition, we thank Drs. Stefano Vicini, Marek Brodzki, Gary Iacobucci, and Robert Pearce for helpful discussions regarding kinetic analysis of single-channel data and simulation of macroscopic currents.
The authors declare no competing financial interests.
Correspondence should be addressed to Wei Lu at luw4{at}mail.nih.gov