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Cover ArticleResearch Articles, Development/Plasticity/Repair

Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons

Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer and Barbara Y. Braz
Journal of Neuroscience 23 November 2022, 42 (47) 8767-8779; DOI: https://doi.org/10.1523/JNEUROSCI.1992-21.2022
Ettel Keifman
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Camila Coll
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Cecilia Tubert
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Rodrigo M. Paz
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Juan E. Belforte
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Mario G. Murer
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Barbara Y. Braz
Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1992-21.2022
PubMed 
36241384
Published By 
Society for Neuroscience
History 
  • Received September 29, 2021
  • Revision received July 13, 2022
  • Accepted September 6, 2022
  • First published October 14, 2022.
  • Version of record published November 23, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Ettel Keifman*,
  2. Camila Coll*,
  3. Cecilia Tubert,
  4. Rodrigo M. Paz,
  5. Juan E. Belforte,
  6. Mario G. Murer, and
  7. Barbara Y. Braz
  1. Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay, Grupo de Neurociencia de Sistemas, 2155 Paraguay St, Buenos Aires, 1121, Argentina
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Author contributions

  1. Author contributions: E.K., C.C., C.T., R.M.P., and B.Y.B. performed research; E.K., C.C., C.T., R.M.P., J.E.B., M.G.M., and B.Y.B. analyzed data; E.K., C.C., C.T., R.M.P., and J.E.B. edited the paper; J.E.B., M.G.M., and B.Y.B. designed research; M.G.M. and B.Y.B. wrote the paper; B.Y.B. wrote the first draft of the paper.

  2. ↵*E.K. and C.C. contributed equally to this work.

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Disclosures

    • Received September 29, 2021.
    • Revision received July 13, 2022.
    • Accepted September 6, 2022.
  • This work was supported by Fondo para la Investigación Científica y Tecnológica Proyecto de Investigación Científica y Tecnológica Grants 2015-3687, 2017-0520, and 2018-2738; and Universidad de Buenos Aires UBACYT 2018-305A. We thank Verónica Risso, Yamila Baez, Analía Lopez Diaz, Jésica Unger, Graciela Ortega, and Bárbara Giugovaz for excellent technical assistance; Juan Ferrario for providing D1-Cre mice; and Gabriela Nieva for help with neonatal lesions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Barbara Y. Braz at barbybraz{at}gmail.com or Mario G. Murer at gmurer{at}fmed.uba.ar

Funding

  • MINCyT | ANPCyT | Fondo para la Investigación Científica y Tecnológica (FonCyT)

    PICT 2015-3687; PICT 2017-0520; PICT 2018-2738
  • Universidad de Buenos Aires (UBA)

    UBACYT 2018-305A

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  • previous version (October 14, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (47)
Journal of Neuroscience
Vol. 42, Issue 47
23 Nov 2022
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Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons
Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer, Barbara Y. Braz
Journal of Neuroscience 23 November 2022, 42 (47) 8767-8779; DOI: 10.1523/JNEUROSCI.1992-21.2022

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Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons
Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer, Barbara Y. Braz
Journal of Neuroscience 23 November 2022, 42 (47) 8767-8779; DOI: 10.1523/JNEUROSCI.1992-21.2022
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Keywords

  • corticostriatal system
  • development
  • dopamine
  • in vivo recordings
  • medium spiny neurons
  • striatum

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