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Featured ArticleResearch Articles, Cellular/Molecular

HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity

Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho and Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: https://doi.org/10.1523/JNEUROSCI.0735-22.2022
Jixiang Zhang (张吉祥)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Shao-Rui Chen (陈少瑞)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Meng-Hua Zhou (周孟华)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Daozhong Jin (金道忠)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Hong Chen (陈红)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Li Wang (王力)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Ronald A. DePinho
2Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Hui-Lin Pan (潘惠麟)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0735-22.2022
PubMed 
36257688
Published By 
Society for Neuroscience
History 
  • Received April 13, 2022
  • Revision received October 3, 2022
  • Accepted October 10, 2022
  • First published October 18, 2022.
  • Version of record published November 30, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Jixiang Zhang (张吉祥 )1,
  2. Shao-Rui Chen (陈少瑞 )1,
  3. Meng-Hua Zhou (周孟华 )1,
  4. Daozhong Jin (金道忠 )1,
  5. Hong Chen (陈红 )1,
  6. Li Wang (王力 )1,
  7. Ronald A. DePinho2, and
  8. Hui-Lin Pan (潘惠麟 )1
  1. 1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
  2. 2Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Author contributions

  1. Author contributions: H.-L.P. designed research; J.Z., S.-R.C., M.-H.Z., D.J., H.C., and L.W. performed research; R.A.D. contributed unpublished reagents/analytic tools; J.Z., S.-R.C., M.-H.Z., D.J., H.C., L.W., and H.-L.P. analyzed data; J.Z., S.-R.C., and H.-L.P. wrote the paper.

  2. *J.Z. and S.-R.C. contributed equally to this work.

Disclosures

    • Received April 13, 2022.
    • Revision received October 3, 2022.
    • Accepted October 10, 2022.
  • This work was supported by National Institutes of Health–National Institute of Neurological Disorders and Stroke Grant NS101880 and the N.G. and Helen T. Hawkins Endowment. We thank Sarah Bronson at MD Anderson Cancer Center for proofreading the manuscript.

  • The authors are employees of the University of Texas System, which currently holds a patent for targeting α2δ-1–bound glutamate receptors for treating diseases and disorders.

  • Correspondence should be addressed to Hui-Lin Pan at huilinpan{at}mdanderson.org

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS101880

Other Version

  • previous version (October 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (48)
Journal of Neuroscience
Vol. 42, Issue 48
30 Nov 2022
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HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity
Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho, Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: 10.1523/JNEUROSCI.0735-22.2022

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HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity
Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho, Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: 10.1523/JNEUROSCI.0735-22.2022
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Keywords

  • chromatin
  • dorsal root ganglion
  • epigenetics
  • histone modification
  • synaptic plasticity
  • transcriptomics

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