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Featured ArticleResearch Articles, Cellular/Molecular

HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity

Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho and Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: https://doi.org/10.1523/JNEUROSCI.0735-22.2022
Jixiang Zhang (张吉祥)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Shao-Rui Chen (陈少瑞)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Meng-Hua Zhou (周孟华)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Daozhong Jin (金道忠)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Hong Chen (陈红)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Li Wang (王力)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Ronald A. DePinho
2Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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Hui-Lin Pan (潘惠麟)
1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
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The Journal of Neuroscience: 42 (48)
Journal of Neuroscience
Vol. 42, Issue 48
30 Nov 2022
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HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity
Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho, Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: 10.1523/JNEUROSCI.0735-22.2022

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HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity
Jixiang Zhang (张吉祥), Shao-Rui Chen (陈少瑞), Meng-Hua Zhou (周孟华), Daozhong Jin (金道忠), Hong Chen (陈红), Li Wang (王力), Ronald A. DePinho, Hui-Lin Pan (潘惠麟)
Journal of Neuroscience 30 November 2022, 42 (48) 8918-8935; DOI: 10.1523/JNEUROSCI.0735-22.2022
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Keywords

  • chromatin
  • dorsal root ganglion
  • epigenetics
  • histone modification
  • synaptic plasticity
  • transcriptomics

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