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Cover ArticleResearch Articles, Neurobiology of Disease

Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel and Jonathan P. Godbout
Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: https://doi.org/10.1523/JNEUROSCI.1377-22.2022
Lynde M. Wangler
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Chelsea E. Bray
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
4College of Medicine, The Ohio State University, Columbus, Ohio 43210
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Jonathan M. Packer
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Zoe M. Tapp
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Amara C. Davis
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Shane M. O'Neil
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Kara Baetz
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Michelle Ouviña
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Mollie Witzel
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
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Jonathan P. Godbout
1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
3Chronic Brain Injury Program, The Ohio State University, Columbus, Ohio 43210
4College of Medicine, The Ohio State University, Columbus, Ohio 43210
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1377-22.2022
PubMed 
36257689
Published By 
Society for Neuroscience
History 
  • Received July 14, 2022
  • Revision received September 7, 2022
  • Accepted September 12, 2022
  • First published October 18, 2022.
  • Version of record published November 30, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Lynde M. Wangler1,2,*,
  2. Chelsea E. Bray2,4,*,
  3. Jonathan M. Packer1,2,
  4. Zoe M. Tapp1,2,
  5. Amara C. Davis1,2,
  6. Shane M. O'Neil1,2,
  7. Kara Baetz1,
  8. Michelle Ouviña1,
  9. Mollie Witzel1, and
  10. Jonathan P. Godbout1,2,3,4
  1. 1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
  2. 2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210
  3. 3Chronic Brain Injury Program, The Ohio State University, Columbus, Ohio 43210
  4. 4College of Medicine, The Ohio State University, Columbus, Ohio 43210
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Author contributions

  1. Author contributions: L.M.W., C.E.B., J.M.P., and J.P.G. designed research; L.M.W., C.E.B., J.M.P., A.C.D., K.B., M.O., and M.W. performed research; L.M.W., C.E.B., J.M.P., Z.M.T., and S.M.O. analyzed data; L.M.W., C.E.B., and J.P.G. wrote the paper.

  2. ↵*L.M.W. and C.E.B. contributed equally to this work.

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Disclosures

    • Received July 14, 2022.
    • Revision received September 7, 2022.
    • Accepted September 12, 2022.
  • This research was supported by National Institute of Health Grants R01-AG-051902 and R01-NS-118037 to J.P.G. L.M.W., J.M.P., and A.C.D. were supported by The Ohio State University (OSU) Distinguished University Fellowships. S.M.O. was supported by an OSU Dean's Distinguished University Fellowship. C.E.B. was supported by the OSU College of Medicine Samuel J. Roessler Scholarship. Z.M.T. was supported by National Institute of Neurological Disorders and Stroke (NINDS) Neuroimmunology Training Grant T32-NS-105864. In addition, this work was supported by NINDS P30 Core Grant P30-NS-045758 to the Center for Brain and Spinal Cord Repair. We thank Dr. Paolo Fadda at The Ohio State University Comprehensive Cancer Center Genomics Shared Resource (under Grant P30-CA-016058), and the Chronic Brain Injury Program, Discovery Themes Initiative at The Ohio State University.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jonathan P. Godbout at Jonathan.Godbout{at}osumc.edu

Funding

  • National Institute of Health

    R01-AG051902; R01-NS118037
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    T32-NS-105864; P30-NS-045758

Other Version

  • previous version (October 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (48)
Journal of Neuroscience
Vol. 42, Issue 48
30 Nov 2022
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Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel, Jonathan P. Godbout
Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: 10.1523/JNEUROSCI.1377-22.2022

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Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel, Jonathan P. Godbout
Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: 10.1523/JNEUROSCI.1377-22.2022
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Keywords

  • aging
  • interferon
  • microglia
  • neuroinflammation
  • STING
  • traumatic brain injury

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