Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Lynde M. Wangler; Chelsea E. Bray; Jonathan M. Packer; Zoe M. Tapp; Amara C. Davis; Shane M. O'Neil; Kara Baetz; Michelle Ouviña; Mollie Witzel; Jonathan P. Godbout

doi:10.1523/JNEUROSCI.1377-22.2022

Cover ArticleResearch Articles, Neurobiology of Disease

Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel and Jonathan P. Godbout

Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: https://doi.org/10.1523/JNEUROSCI.1377-22.2022

Lynde M. Wangler

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Chelsea E. Bray

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

4College of Medicine, The Ohio State University, Columbus, Ohio 43210

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Jonathan M. Packer

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Zoe M. Tapp

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Amara C. Davis

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Shane M. O'Neil

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Kara Baetz

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Michelle Ouviña

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Mollie Witzel

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

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Jonathan P. Godbout

1Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

2Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210

3Chronic Brain Injury Program, The Ohio State University, Columbus, Ohio 43210

4College of Medicine, The Ohio State University, Columbus, Ohio 43210

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Vol. 42, Issue 48

30 Nov 2022

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Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel, Jonathan P. Godbout

Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: 10.1523/JNEUROSCI.1377-22.2022

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Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouviña, Mollie Witzel, Jonathan P. Godbout

Journal of Neuroscience 30 November 2022, 42 (48) 9082-9096; DOI: 10.1523/JNEUROSCI.1377-22.2022

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aging
interferon
microglia
neuroinflammation
STING
traumatic brain injury

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