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Research Articles, Cellular/Molecular

Differential Regulation of the BDNF Gene in Cortical and Hippocampal Neurons

Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi and Tõnis Timmusk
Journal of Neuroscience 7 December 2022, 42 (49) 9110-9128; DOI: https://doi.org/10.1523/JNEUROSCI.2535-21.2022
Eli-Eelika Esvald
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
2Protobios LLC, Tallinn 12618, Estonia
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Jürgen Tuvikene
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
2Protobios LLC, Tallinn 12618, Estonia
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  • ORCID record for Jürgen Tuvikene
Andra Moistus
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
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Käthy Rannaste
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
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Susann Kõomägi
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
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Tõnis Timmusk
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
2Protobios LLC, Tallinn 12618, Estonia
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2535-21.2022
PubMed 
36316156
Published By 
Society for Neuroscience
History 
  • Received December 27, 2021
  • Revision received September 18, 2022
  • Accepted October 19, 2022
  • First published October 31, 2022.
  • Version of record published December 7, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Eli-Eelika Esvald1,2,
  2. Jürgen Tuvikene1,2,*,
  3. Andra Moistus1,*,
  4. Käthy Rannaste1,
  5. Susann Kõomägi1, and
  6. Tõnis Timmusk1,2
  1. 1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
  2. 2Protobios LLC, Tallinn 12618, Estonia
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Author contributions

  1. Author contributions: E.-E.E., J.T., and T.T. designed research; E.-E.E., J.T., A.M., K.R., and S.K. performed research; E.-E.E., J.T., A.M., K.R., and S.K. analyzed data; E.-E.E. wrote the first draft of the paper; E.-E.E., J.T., and T.T. edited the paper; E.-E.E. and J.T. wrote the paper.

  2. ↵*J.T. and A.M. contributed equally to this work.

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Disclosures

    • Received December 27, 2021.
    • Revision received September 18, 2022.
    • Accepted October 19, 2022.
  • This work was supported by the Estonian Research Council Grant PRG805 and the European Union through the European Regional Development Fund Project No. 2014-2020.4.01.15-0012 and H2020-MSCA-RISE-2016 (EU734791). We thank the TUT Institutional Development Program for 2016–2022 Graduate School in Clinical Medicine, which received funding from the European Regional Development Fund under Program ASTRA 2014-2020.4.01.16-0032 in Estonia. We thank Epp Väli for technical assistance and Priit Pruunsild, Indrek Koppel, Florencia Cabrera-Cabrera, and Annela Avarlaid for critical reading of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Tõnis Timmusk at tonis.timmusk{at}taltech.ee or Eli-Eelika Esvald at eli-eelika.esvald{at}taltech.ee

Funding

  • Eesti Teadusagentuur (ETAg)

    PRG805
  • European Regional Development Fund

    2014-2020.4.01.15-0012; 2014-2020.4.01.16-0032
  • EC | Horizon 2020 (EU Framework Programme for Research and Innovation)

    EU734791

Other Version

  • previous version (October 31, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (49)
Journal of Neuroscience
Vol. 42, Issue 49
7 Dec 2022
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Differential Regulation of the BDNF Gene in Cortical and Hippocampal Neurons
Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmusk
Journal of Neuroscience 7 December 2022, 42 (49) 9110-9128; DOI: 10.1523/JNEUROSCI.2535-21.2022

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Differential Regulation of the BDNF Gene in Cortical and Hippocampal Neurons
Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmusk
Journal of Neuroscience 7 December 2022, 42 (49) 9110-9128; DOI: 10.1523/JNEUROSCI.2535-21.2022
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Keywords

  • BDNF cortex
  • CREB
  • hippocampus
  • neuronal activity

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